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  4. LQFM215

LQFM215 is a proline transporter (PROT) inhibitor. LQFM215 inhibits proline transport by competitively binding to the active site of PROT. LQFM215 effectively reduces hyperlocomotion and enhances social interaction.

For research use only. We do not sell to patients.

LQFM215 Chemical Structure

LQFM215 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 99 In-stock
Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Solid
5 mg USD 90 In-stock
10 mg USD 163 In-stock
25 mg USD 360 In-stock
50 mg USD 652 In-stock
100 mg USD 1175 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

LQFM215 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

LQFM215 is a proline transporter (PROT) inhibitor. LQFM215 inhibits proline transport by competitively binding to the active site of PROT. LQFM215 effectively reduces hyperlocomotion and enhances social interaction[1].

In Vitro

LQFM215 (0.39-100 μM; 24 h ) shows low neurotoxicity against LUHMES cells[1].
LQFM215 (0.09-100 μM; 24 h ) shows concentration-dependent effects on growth of differentiated neural protrusions and cell survival in LUHMES cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LQFM215 Related Antibodies

Cell Viability Assay[1]

Cell Line: LUHMES cells
Concentration: 0.09-100 μM
Incubation Time: 24 h
Result: During the developmental phase, neural protrusion formation was inhibited at an IC50 of 3 μM. During maturation, a concentration of 14 μM IC50 reduced neural protrusion growth and cell survival.

Cell Cytotoxicity Assay[1]

Cell Line: LUHMES cells
Concentration: 0.39-100 μM
Incubation Time: 24 h
Result: Reduced cell viability and neural protrusion growth in LUHMES cells, but this effect was mitigated when co-cultured with astrocytes
In Vivo

LQFM215 (i.p.; 10-30 mg/kg; single dose) significantly reduces ketamine-induced hyperlocomotion in Swiss mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice [1]
Dosage: 10; 20; 30 mg/kg
Administration: i.p.; single dose
Result: Increased the time spent in social interaction with an intruder animal in ketamine-treated mice across all doses, particularly at 10 mg/kg and 20 mg/kg. Increased the number of social interactions at 30 mg/kg.
Molecular Weight

394.55

Formula

C25H34N2O2
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)N(CC2)CCN2C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (253.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5345 mL 12.6727 mL 25.3453 mL
5 mM 0.5069 mL 2.5345 mL 5.0691 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.34 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5345 mL 12.6727 mL 25.3453 mL 63.3633 mL
5 mM 0.5069 mL 2.5345 mL 5.0691 mL 12.6727 mL
10 mM 0.2535 mL 1.2673 mL 2.5345 mL 6.3363 mL
15 mM 0.1690 mL 0.8448 mL 1.6897 mL 4.2242 mL
20 mM 0.1267 mL 0.6336 mL 1.2673 mL 3.1682 mL
25 mM 0.1014 mL 0.5069 mL 1.0138 mL 2.5345 mL
30 mM 0.0845 mL 0.4224 mL 0.8448 mL 2.1121 mL
40 mM 0.0634 mL 0.3168 mL 0.6336 mL 1.5841 mL
50 mM 0.0507 mL 0.2535 mL 0.5069 mL 1.2673 mL
60 mM 0.0422 mL 0.2112 mL 0.4224 mL 1.0561 mL
80 mM 0.0317 mL 0.1584 mL 0.3168 mL 0.7920 mL
100 mM 0.0253 mL 0.1267 mL 0.2535 mL 0.6336 mL
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LQFM215 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LQFM215LQFM 215LQFM-215OthersLUHMESschizophreniapsychosisInhibitorinhibitorinhibit

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