2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Amylases

Amylases

Amylases are crucial enzymes which hydrolyze internal glycosidic linkages in starch and produce as primary products dextrins and oligosaccharides. Amylases are classified into α-amylase, β-amylase, and glucoamylase based on their three-dimensional structures, reaction mechanisms, and amino acid sequences. Amylases have innumerable applications in clinical, medical, and analytical chemistries as well as in food, detergent, textile, brewing, and distilling industries.

Amylases Related Products (59):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-168961
    α-Amylase/α-Glucosidase-IN-18
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-18 (Compound 9g) is the inhibitor for α-Amylase and α-Glucosidase with IC50 of 49.17 nM and 10.71 nM. α-Amylase/α-Glucosidase-IN-18 can be used in research of type 2 diabetes mellitus.
    α-Amylase/α-Glucosidase-IN-18
  • HY-155961
    Antidiabetic agent 2
    		Inhibitor
    Antidiabetic agent 2 (Compound 56) is a glucose-uptake promoter. Antidiabetic agent 2 inhibits DPP-4, PTP-1B, α-amylase, and α-glucosidase with IC50s of 0.036, 0.042, 0.241, 0.185 μM. Antidiabetic agent 2 decreases blood glucose levels.
    Antidiabetic agent 2
  • HY-161764
    α-Glucosidase-IN-67
    		Inhibitor
    α-Glucosidase-IN-67 (compound 5k) is a potent α-Glucosidase inhibitor with IC50 values of 0.31, 4.51 µM for alpha-glucosidase and alpha-amylase, respectively. α-Glucosidase-IN-67 has the potential for the research of type-2 diabetes.
    α-Glucosidase-IN-67
  • HY-N9916
    8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside
    		Inhibitor
    8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside (Compound 3) is natural product that can be isolated from Bidens bipinnata. 8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside shows 22% inhibition against α-amylase at 0.556 mg/mL.
    8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside
  • HY-163439
    α-Amylase/α-Glucosidase-IN-12
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-12 (compound 10k) is a dual inhibitor targeting α-glucosidase and α-amylase with IC50 of 34.52 nM and 24.62 nM, respectively. α-Amylase/α-Glucosidase-IN-12 is an inhibitor designed based on triazolo[4,3-b][1,2,4]triazine and has the potential to be used in diabetes research.
    α-Amylase/α-Glucosidase-IN-12
  • HY-172211
    α-Amylase/α-Glucosidase-IN-17
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-17 (Compound 3) is an inhibitor of α-amylase and α-glucosidase, with IC50 values of 14.61 μM and 25.38 μM, respectively. α-Amylase/α-Glucosidase-IN-17 has certain inhibitory activity against A549 cancer cells. α-Amylase/α-Glucosidase-IN-17 has anti-tumor and anti-diabetic effects.
    α-Amylase/α-Glucosidase-IN-17
  • HY-157537
    α-Amylase-IN-5
    		Inhibitor
    α-Amylase-IN-5 (compound 3a) is a α-amylase inhibitor, with an IC50 of 18.8 mM.
    α-Amylase-IN-5
  • HY-161944
    α-Amylase-IN-8
    		Inhibitor
    α-Amylase-IN-8 (compound 44) ​​is an α-amylase inhibitor (IC50=58.1 μM). α-Amylase-IN-8 can be used in the research of type 2 diabetes.
    α-Amylase-IN-8
  • HY-149313
    α‑Amylase-IN-1
    		Inhibitor 98.33%
    α Amylase-IN-1 (Compound 11) is an α-Amylase inhibitor with an IC50 value of 0.5509 μM. α Amylase-IN-1 has antioxidant activity with an IC50 value of 53.49 μM for scavenging DPPH free radicals. IC50 can be used in the study of diabetes and oxidative stress-related diseases.
    α‑Amylase-IN-1
  • HY-N12263
    3,5,6,7,8,4'-Hexamethoxyflavone
    		Inhibitor
    3,5,6,7,8,4'-Hexamethoxyflavone is a inhibitor of α-Amylase with the inhibitory activity of 28.3% at 500 μM.
    3,5,6,7,8,4'-Hexamethoxyflavone
  • HY-B2193C
    α-Amylase, Porcine Pancreatic
    α-Amylase, Porcine Pancreatic (1,4-alpha-D-Glucan-glucanohydrolase, amy2, PPA, PA) is a biological material or organic compound that can be used in life science research.
    α-Amylase, Porcine Pancreatic
  • HY-149973
    α-Amylase-IN-4
    α-Amylase-IN-4 (Compd 10y) show maximum inhibition of amylase activity with IC50 value 17.83 ± 0.14 μg/mL.
    α-Amylase-IN-4
  • HY-161461
    E234G HYPE-IN-1
    		Inhibitor
    E234G HYPE-IN-1 (Compound I2.10) is an inhibitor of AMPylation directed by the Huntingtin-interacting protein E (HYPE), possessing low micromolar bioactivity, low cytotoxicity, and blood-brain barrier permeability. E234G HYPE-IN-1 can inhibit the AMPylation of B-cell immunoglobulin-binding protein (BiP), the primary substrate of HYPE. E234G HYPE-IN-1 is suitable for development as a HYPE-specific therapeutic agent for clinical conditions such as neurodegenerative diseases and diabetes.
    E234G HYPE-IN-1
  • HY-159491
    DPP-4-IN-11
    		Inhibitor
    DPP-4-IN-11 (compound 10) is an orally active DPP-4 inhibitor (IC50=2.75 μM) with anti-type 2 diabetes activity. DPP-4-IN-11 exerts its glucose-lowering effect by inhibiting the activities of α-glucosidase (IC50=3.02 μM) and α-amylase (IC50=3.3 μM).
    DPP-4-IN-11
  • HY-162634
    α-Amylase/α-Glucosidase-IN-15
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-15 (compound 6C) is an oral bioactive inhibitor of α-Glucosidase and α-amylase, with the IC50s of 21 μM and 61 μM, respectively.
    α-Amylase/α-Glucosidase-IN-15
  • HY-146752
    α-Amylase-IN-1
    α-Amylase-IN-1 is a potent α-amylase inhibitor with an IC50 of 4.46 μM.
    α-Amylase-IN-1
  • HY-168598
    α-Amylase-IN-9
    		Inhibitor
    α-Amylase-IN-9 (Compound 1i) is an inhibitor of α-Amylase with an IC50 value of 14.64 μM, which can be used in diabetes research.
    α-Amylase-IN-9
  • HY-168074
    4″-C18 EGCG
    		Inhibitor
    4″-C18 EGCG is a potent inhibitor of α-amylase and α-glucosidase with IC50 values of 3.74 and 0.81 μM, respectively. 4″-C18 EGCG inhibits carbohydrate hydrolases, reduces oxidative stress and inflammation, and exhibits antidiabetic activity. 4″-C18 EGCG also downregulates proinflammatory cytokines and is cytotoxic to primary human peripheral blood mononuclear cells (PBMCs), non-cancer cell lines 3T3-L1, and HEK 293 at 50 μM.
    4″-C18 EGCG
  • HY-161469
    α-Amylase/α-Glucosidase-IN-13
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-13 (Compound 5d) is a dual inhibitor of α-Amylase/α-Glucosidase that can be used for diabetes research.
    α-Amylase/α-Glucosidase-IN-13
  • HY-162390
    α-Amylase/α-Glucosidase-IN-11
    		Inhibitor
    α-Amylase/α-Glucosidase-IN-11 (Compound 5d) is a isoxazolidine-isatin hybrid with significant antidiabetic activity. α-Amylase/α-Glucosidase-IN-11 competitively inhibits α-amylase (IC50 = 30.39 μM) and α-glucosidase (IC50 = 65.1 μM), two key digestive enzymes. α-Amylase/α-Glucosidase-IN-11 does not cross the blood-brain barrier.
    α-Amylase/α-Glucosidase-IN-11