2. Anti-infection Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Antibiotic HSP
  4. Isoxazole

Isoxazole possesses broad biological activities with low cytotoxicity (e.g. anti-microbial, antibacterial, antifungal, anti-viral, anti-cancer, anti-inflammatory, immunomodulatory, analgesic, antituberculous or anti-diabetic properties), which is a member of five-membered heterocycles for a agent scaffold. Isoxazole with reversed ring can be used as HSP90 inhibitor. Isoxazole has been explored as BET bromodomain inhibitor and tricyclic Isoxazole is a promising for selective multidrug resistance protein (MRP1) inhibitors. Isoxazole is promising for research of various inhibitors and diseases.

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Isoxazole Chemical Structure

Isoxazole Chemical Structure

CAS No. : 288-14-2

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Based on 1 publication(s) in Google Scholar

Isoxazole Related Antibodies

Top Publications Citing Use of Products

View All Antibiotic Isoform Specific Products:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

View All HSP Isoform Specific Products:

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Description

Isoxazole possesses broad biological activities with low cytotoxicity (e.g. anti-microbial, antibacterial, antifungal, anti-viral, anti-cancer, anti-inflammatory, immunomodulatory, analgesic, antituberculous or anti-diabetic properties), which is a member of five-membered heterocycles for a agent scaffold. Isoxazole with reversed ring can be used as HSP90 inhibitor. Isoxazole has been explored as BET bromodomain inhibitor and tricyclic Isoxazole is a promising for selective multidrug resistance protein (MRP1) inhibitors. Isoxazole is promising for research of various inhibitors and diseases[1][2][3][4].

Molecular Weight

69.06

Formula

C3H3NO
CAS No.
Appearance

Liquid (Density: 1.078 g/cm3)

Color

Colorless to light yellow

SMILES

C1=CON=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (1447.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 14.4795 mL 72.3977 mL 144.7953 mL
5 mM 2.8959 mL 14.4795 mL 28.9591 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.98%

SDS (466 KB)

COA (259 KB) HNMR (111 KB) GC (184 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 14.4795 mL 72.3977 mL 144.7953 mL 361.9883 mL
5 mM 2.8959 mL 14.4795 mL 28.9591 mL 72.3977 mL
10 mM 1.4480 mL 7.2398 mL 14.4795 mL 36.1988 mL
15 mM 0.9653 mL 4.8265 mL 9.6530 mL 24.1326 mL
20 mM 0.7240 mL 3.6199 mL 7.2398 mL 18.0994 mL
25 mM 0.5792 mL 2.8959 mL 5.7918 mL 14.4795 mL
30 mM 0.4827 mL 2.4133 mL 4.8265 mL 12.0663 mL
40 mM 0.3620 mL 1.8099 mL 3.6199 mL 9.0497 mL
50 mM 0.2896 mL 1.4480 mL 2.8959 mL 7.2398 mL
60 mM 0.2413 mL 1.2066 mL 2.4133 mL 6.0331 mL
80 mM 0.1810 mL 0.9050 mL 1.8099 mL 4.5249 mL
100 mM 0.1448 mL 0.7240 mL 1.4480 mL 3.6199 mL
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Isoxazole Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isoxazole288-14-2AntibioticHSPHeat shock proteinslow cytotoxicitybroad biological activitiesagent scaffoldinhibitorInhibitorinhibit

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