2. Signaling Pathways
  3. Anti-infection
  4. Beta-lactamase

Beta-lactamase

β-lactamase

Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.

Beta-lactamase Isoform Specific Products:

Beta-lactamase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0593A
    Ceftazidime pentahydrate
    		Inhibitor 99.87%
    Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases.
    Ceftazidime pentahydrate
  • HY-B1256A
    Cefuroxime
    		Inhibitor 99.08%
    Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria.
    Cefuroxime
  • HY-B1275A
    Cephalothin
    		Inhibitor 99.34%
    Cephalotin (Cephalotin) is a beta-lactam antibiotic, inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM.
    Cephalothin
  • HY-B1434
    7-Aminocephalosporanic acid
    		Inhibitor ≥98.0%
    7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor.
    7-Aminocephalosporanic acid
  • HY-A0256B
    Clavulanate lithium
    		Inhibitor 99.64%
    Clavulanate lithium is a potent β-lactamase inhibitor and acts as an antibiotic.
    Clavulanate lithium
  • HY-17452
    Cefditoren sodium
    		Inhibitor 99.70%
    Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
    Cefditoren sodium
  • HY-132987
    Avibactam tomilopil
    		Inhibitor 99.66%
    Avibactam tomilopil (ARX-1796, AV-006) is an orally active prodrug of Avibactam and a β-lactamase inhibitor. Avibactam tomilopil can be used in the study of diseases such as urinary tract infections.
    Avibactam tomilopil
  • HY-108062A
    BLI-489 hydrate
    		Inhibitor ≥99.0%
    BLI-489 hydrate, a penem β-lactamase inhibitor, is active against class A and class C as well as some class D β-lactamases. The combination of Piperacillin and BLI-489 hydrate is efficacious against murine infections caused by class A (including extended-spectrum β-lactamases), class C (AmpC), and class D β-lactamase-expressing pathogens.
    BLI-489 hydrate
  • HY-19964
    Potassium clavulanate cellulose
    		Inhibitor ≥98.0%
    Potassium clavulanate cellulose (Potassium clavulanate:cellulose (1:1)) is a mixture of potassium clavulanate and cellulose, is a bacterial β-lactamase inhibitor. Clavulanate potassium is a form of Clavulanic acid. Clavulanate potassium fights bacteria that resistant to penicillins and other antibiotics. Potassium clavulanate with the combination of amoxicillin can be used for the research of different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin.
    Potassium clavulanate cellulose
  • HY-141808
    AZD-CO-Ph-PEG4-Ph-CO-AZD
    AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker can be used for antibody-siRNA conjugate synthesis.
    AZD-CO-Ph-PEG4-Ph-CO-AZD
  • HY-132823
    Ledaborbactam
    		Inhibitor 99.12%
    Iedaborbactam (VNRX-5236), as a β-lactamase inhibitor (WO2015191907, Example 62), can be used for the research of bacterial infections.
    Ledaborbactam
  • HY-16745
    Lascufloxacin
    		Inhibitor 98.04%
    Lascufloxacin (KRP-AM1977X) is a potent and orally active fluoroquinolone antibacterial agent. Lascufloxacin potently inhibits infections caused by various pathogens, including quinolone-resistant strains. Lascufloxacin has the potential for various infectious diseases treatment, including lower respiratory tract infections.
    Lascufloxacin
  • HY-154438
    RDR 02308
    		Inhibitor ≥98.0%
    RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase.
    RDR 02308
  • HY-147274
    Funobactam
    		Inhibitor 99.47%
    Funobactam (XNW4107) is a β-lactamase inhibitor, can be used for researching anti-bacteria.
    Funobactam
  • HY-125604
    WCK-4234
    		Inhibitor ≥98.0%
    WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases.
    WCK-4234
  • HY-139745
    FPI-1523 sodium
    		Inhibitor 99.79%
    FPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity.
    FPI-1523 sodium
  • HY-B1923S
    Piperacillin-d5
    		Inhibitor
    Piperacillin-d5 is deuterium labeled Piperacillin. Piperacillin is kind of semisynthetic penicillins. Piperacillin has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Piperacillin has shown greater activity against β-lactamase-producing organisms than the other penicillins[1].
    Piperacillin-d<sub>5</sub>
  • HY-108288
    Sulbactam pivoxil
    		Inhibitor ≥98.0%
    Sulbactam pivoxil is a proagent of sulbactam. Sulbactam is a β-lactamase inhibitor which poorly adsorbed from gastrointestinal tract. Sulbactam pivoxil has a better absorption than the parent agent and provides high serum levels after oral administration.
    Sulbactam pivoxil
  • HY-150758
    NDM-1 inhibitor-3
    		Inhibitor 99.41%
    NDM-1 inhibitor-3 (Compound 89) is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor with a Ki of 4 μM.
    NDM-1 inhibitor-3
  • HY-136306
    Metallo β-lactamase ligand 1
    		Inhibitor 99.60%
    Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A.
    Metallo β-lactamase ligand 1
Beta-lactamase Isoform Comparison

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