2. Immunology/Inflammation Anti-infection
  3. Beta-lactamase Toll-like Receptor (TLR) Bacterial
  4. RDR 02308

RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase.

For research use only. We do not sell to patients.

RDR 02308 Chemical Structure

RDR 02308 Chemical Structure

CAS No. : 4155-82-2

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
5 mg USD 150 In-stock
10 mg USD 240 In-stock
25 mg USD 480 In-stock
50 mg USD 770 In-stock
100 mg USD 1230 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

RDR 02308 Related Antibodies

Top Publications Citing Use of Products

View All Beta-lactamase Isoform Specific Products:

View All Isoforms
Metallo-β-lactamase

View All Toll-like Receptor (TLR) Isoform Specific Products:

View All Isoforms
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase[1].

In Vitro

RDR 02308 (0-10 μM; 1 h) inhibits LPS (HY-D1056)-mediated IL-6 production in RAW264.7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RDR 02308 Related Antibodies

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 0-10 μM
Incubation Time: 1 h
Result: Inhibited LPS-mediated IL-6 production.
Molecular Weight

333.34

Formula

C19H15N3O3
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=[N+](C1=CC=C(C2=NN(C3=CC=CC=C3)C(C4=CC=CO4)C2)C=C1)[O-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (299.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9999 mL 14.9997 mL 29.9994 mL
5 mM 0.6000 mL 2.9999 mL 5.9999 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9999 mL 14.9997 mL 29.9994 mL 74.9985 mL
5 mM 0.6000 mL 2.9999 mL 5.9999 mL 14.9997 mL
10 mM 0.3000 mL 1.5000 mL 2.9999 mL 7.4999 mL
15 mM 0.2000 mL 1.0000 mL 2.0000 mL 4.9999 mL
20 mM 0.1500 mL 0.7500 mL 1.5000 mL 3.7499 mL
25 mM 0.1200 mL 0.6000 mL 1.2000 mL 2.9999 mL
30 mM 0.1000 mL 0.5000 mL 1.0000 mL 2.5000 mL
40 mM 0.0750 mL 0.3750 mL 0.7500 mL 1.8750 mL
50 mM 0.0600 mL 0.3000 mL 0.6000 mL 1.5000 mL
60 mM 0.0500 mL 0.2500 mL 0.5000 mL 1.2500 mL
80 mM 0.0375 mL 0.1875 mL 0.3750 mL 0.9375 mL
100 mM 0.0300 mL 0.1500 mL 0.3000 mL 0.7500 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

RDR 02308 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RDR 023084155-82-2RDR02308RDR-02308Beta-lactamaseToll-like Receptor (TLR)Bacterialβ-lactamaseIL-6RAW264.7LPSInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
RDR 02308
Cat. No.:
HY-154438
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.