AZD-CO-Ph-PEG4-Ph-CO-AZD

Name: AZD-CO-Ph-PEG4-Ph-CO-AZD
Brand: MedChemExpress
SKU: HY-141808
Rating: 4.5 (1 reviews)

Cat. No.: HY-141808 Purity: 96.08%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker can be used for antibody-siRNA conjugate synthesis.

For research use only. We do not sell to patients.

AZD-CO-Ph-PEG4-Ph-CO-AZD Chemical Structure

CAS No. : 2569143-72-0

Size	Price	Stock	Quantity
10 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker can be used for antibody-siRNA conjugate synthesis^[1].

Molecular Weight

496.51

Formula

C₂₆H₂₈N₂O₈

CAS No.

2569143-72-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C(CC1)=O)C2=CC=C(C=C2)OCCOCCOCCOC3=CC=C(C(N4C(CC4)=O)=O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (100.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0141 mL	10.0703 mL	20.1406 mL
5 mM	0.4028 mL	2.0141 mL	4.0281 mL
10 mM	0.2014 mL	1.0070 mL	2.0141 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 96.08%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (243 KB) HNMR (265 KB) RP-HPLC (211 KB) MS (176 KB)

Handling Instructions (2659 KB)

References

[1]. Alex R Nanna, et al.Generation and validation of structurally defined antibody-siRNA conjugates. Nucleic Acids Res. 2020 Jun 4;48(10):5281-5293. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0141 mL	10.0703 mL	20.1406 mL	50.3515 mL
	5 mM	0.4028 mL	2.0141 mL	4.0281 mL	10.0703 mL
	10 mM	0.2014 mL	1.0070 mL	2.0141 mL	5.0351 mL
	15 mM	0.1343 mL	0.6714 mL	1.3427 mL	3.3568 mL
	20 mM	0.1007 mL	0.5035 mL	1.0070 mL	2.5176 mL
	25 mM	0.0806 mL	0.4028 mL	0.8056 mL	2.0141 mL
	30 mM	0.0671 mL	0.3357 mL	0.6714 mL	1.6784 mL
	40 mM	0.0504 mL	0.2518 mL	0.5035 mL	1.2588 mL
	50 mM	0.0403 mL	0.2014 mL	0.4028 mL	1.0070 mL
	60 mM	0.0336 mL	0.1678 mL	0.3357 mL	0.8392 mL
	80 mM	0.0252 mL	0.1259 mL	0.2518 mL	0.6294 mL
	100 mM	0.0201 mL	0.1007 mL	0.2014 mL	0.5035 mL