CD73 Inhibitor

CD73 Inhibitors (39):

Cat. No.	Product Name	Effect	Purity

HY-125286

AB-680	Inhibitor	99.71%
AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a K_i of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity.

HY-P99039

Oleclumab	Inhibitor	99.90%
Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity.

HY-100747

PSB-12379	Inhibitor	99.54%
PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with K_is of 9.03 nM (rat) and 2.21 nM (human).

HY-P99181

Mupadolimab	Inhibitor	99.43%
Mupadolimab (CPI-006) is an IgG1κ humanized FcγR binding-deficient anti-CD73 monoclonal antibody (mAb) that activates CD73^POS B cells.

HY-112502C

MethADP triammonium	Inhibitor	99.03%
MethADP (Adenosine 5'-(α,β-methylene)diphosphate) triammonium is a CD73 inhibitor. MethADP can be used for the research of ATP-adenosine pathway.

HY-112502D

MethADP trisodium	Inhibitor
MethADP (Adenosine 5'-(α,β-methylene)diphosphate) (trisodium) is a CD73 inhibitor. MethADP (trisodium) can be used for the research of ATP-adenosine pathway.

HY-162918

CD73-IN-17	Inhibitor
CD73-IN-17 (compound 19) is a CD73 inhibitor with IC₅₀ of 0.1 μM for hCD73. CD73-IN-17 can be used in anti-cancer research.

HY-161774

ST80	Inhibitor
ST80 is an inhibitor for interaction of OTUD4 and CD73. ST80 decreases CD73 protein level, increases CD73 protein turnover, reduces immune evasion of tumor cells, and thus exhibits antitumor efficacy against immunosuppressive triple-negative breast cancer (TNBC).

HY-P99169

Uliledlimab	Inhibitor
Uliledlimab is a potent against CD73 humanizedized monoclonal antibody. Uliledlimab inhibits the conversion of extracellular adenosine monophosphate (AMP) to adenosine. Uliledlimab can be used in research of cancer.

HY-112502

MethADP	Inhibitor	≥99.0%
MethADP is a specific CD73 inhibitor.

HY-136978

OP-5244	Inhibitor	99.07%
OP-5244 is a potent and orally active inhibitor of CD73, with an IC₅₀ of 0.25 nM. OP-5244 reverses immunosuppression through blocking of adenosine production, and has the potential for the cancer research.

HY-137246

CD73-IN-3	Inhibitor	99.89%
CD73-IN-3 is a potent CD73 inhibitor (IC₅₀=7.3 nM in Calu6 human cell assay). CD73-IN-3, example 2 extracted from patent WO2019168744 A1, has the potential for cancer research.

HY-103695

CD73-IN-1	Inhibitor	99.46%
CD73-IN-1 is an inhibitor of CD73 which can be used in the treatment of cancer extracted from patent WO 2017153952 A1, example 80.

HY-145334

CD73-IN-5	Inhibitor	98.14%
CD73-IN-5 is a potent and selective non-nucleotide small molecule inhibitor of CD73 (IC₅₀ = 19 nM).

HY-131967

CD73-IN-4	Inhibitor	99.21%
CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC₅₀ of 2.6 nM for human CD73. CD73-IN-4 is potential for the research of cancer immunology.

HY-136978A

OP-5244 sodium	Inhibitor	99.87%
OP-5244 sodium is a potent and orally active inhibitor of CD73, with an IC₅₀ of 0.25 nM. OP-5244 sodium reverses immunosuppression through blocking of adenosine production, and has the potential for the cancer research.

HY-125286A

AB-680 ammonium	Inhibitor
AB-680 ammonium is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a K_i of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity.

HY-112502B

MethADP sodium	Inhibitor
MethADP (sodium salt) (Adenosine 5'-(α,β-methylene)diphosphate (sodium)) is a specific CD73 inhibitor.

HY-160696

ORIC-533	Inhibitor
ORIC-533 is an orally active, selective CD73 inhibitor with AMP-competition. ORIC-533 restores immunosuppressed CD8+ T cell proliferation and activation, triggers significant lysis and cell death of multiple myeloma cells in the bone marrow microenvironment.

HY-147592

CD73-IN-11	Inhibitor
CD73-IN-11 is a potent inhibitor of CD73. CD73 can catalyze the production of adenosine from extracellular 5'-phosphate adenosine (5'-AMP), and adenosine can induce immunosuppressive effects and promote tumor proliferation and/or metastasis. CD73-IN-11 be used for preparing a medicament for tumor-related diseases (extracted from patent WO2022068929A1, compound 24).

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