2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Constitutive Androstane Receptor
  5. Constitutive Androstane Receptor Inhibitor

Constitutive Androstane Receptor Inhibitor

Constitutive Androstane Receptor Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-W722556
    5α-Androstan-3α-ol
    		Inhibitor
    5α-Androstan-3α-ol is a γ-aminobutyric acid (GABA) receptor agonist. 5α-Androstan-3α-ol can inhibit the transcriptional activity of the orphan nuclear receptor CAR (constitutive androstane receptor). 5α-Androstan-3α-ol negatively regulates the activity of CAR by binding to CAR and promoting its dissociation from coactivator proteins. 5α-Androstan-3α-ol can be used to study nuclear receptor-mediated hormone metabolism and drug detoxification mechanisms.
  • HY-110134
    S07662
    		Inhibitor
    S07662 is a human constitutive androstane receptor (hCAR) inhibitor with an IC50 of 0.7 μM. S07662 recruits the corepressor NCoR in cell-based assays and attenuate the expression of CYP2B6 mRNA in human primary hepatocytes induced by phenytoin (HY-B0448) and CITCO (HY-103244).