2. Signaling Pathways
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  4. Drug Derivative

Drug Derivative

Drug derivative

 

Drug Derivative Related Products (291):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P10262
    LL-37-Cys
    LL-37-Cys is a LL-37 (HY-P1222) with a C-terminal reduced cystein residue[1][.
    LL-37-Cys
  • HY-B0236A
    6-Aminocaproic acid hydrochloride
    6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders.
    6-Aminocaproic acid hydrochloride
  • HY-W753724
    N-Ethyl 2C-B hydrochloride
    N-Ethyl 2C-B hydrochloride is a phenethylamine with psychoactive properties.
    N-Ethyl 2C-B hydrochloride
  • HY-105035
    Rodorubicin
    Rodorubicin (Cytorhodin S) is a tetraglycosidic anthracycline with preclinical antitumor activity.
    Rodorubicin
  • HY-121776
    Nicomol
    		98.40%
    Nicomol is an orally active hypolipidemic agent that can increase the high density lipoprotein cholesterol (HDL-C) level. Nicomol inhibits the rapid rise of plasma free fatty acids.
    Nicomol
  • HY-161648
    Anticancer agent 222
    Anticancer agent 222 (Compound 19) is an orally active anticancer agent that exhibits significant anticancer activity against Huh7, FOCUS, SNU475, SNU182, HepG2, and Hep3B cells (IC50 = 2.9–9.3 μM).
    Anticancer agent 222
  • HY-16394
    PG-11047 tetrahydrochloride
    		≥98.0%
    PG-11047 (CGC-11047), a polyamine analogue, is a nonfunctional competitor of the natural polyamine spermine. PG-11047 has broad spectrum anticancer activities.
    PG-11047 tetrahydrochloride
  • HY-19590
    Etarotene
    Etarotene (Ro 15-1570) is a derivative of Arotinoid (HY-106735). Etarotene is an orally active antitumor agent against DMBA (HY-W011845)-induced mammary tumor and causes toxic symptoms of hypervitaminosis A in rat model.
    Etarotene
  • HY-P10490
    (D-His(Bzl)6)-LHRH (1-7) free acid
    (D-His(Bzl)6)-LHRH (1-7) free acid is a synthetic peptide compound that is a derivative of luteinizing hormone-releasing hormone (LHRH). (D-His(Bzl)6)-LHRH (1-7) free acid enhances its stability and biological activity by introducing unnatural amino acid residues at specific positions of the LHRH molecule. This modification can improve the drug's performance in the body half-life, reducing the rate at which it is rapidly metabolized and cleared, thereby enhancing its efficacy in inhibiting cell proliferation.
    (D-His(Bzl)6)-LHRH (1-7) free acid
  • HY-P2269
    MAIT-203
    MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells.
    MAIT-203
  • HY-107008
    SW 71425
    SW 71425 inhibits cell growth against breast, colon, non-small cell lung, and ovarian tumors..
    SW 71425
  • HY-123168
    ZIMET 124/73
    ZIMET 124/73 is a hetarylhydrazone derivative. ZIMET 124/73 is a potent antiviral agent. ZIMET 124/73 can be used for Mengo virus research.
    ZIMET 124/73
  • HY-W141863
    DL-Methionine Sulfone
    DL-Methionine Sulfone is a Methionine (HY-13694) derivative.
    DL-Methionine Sulfone
  • HY-156879
    Antiproliferative agent-40
    Antiproliferative agent-40 (Compound 9) inhibits proliferation of HT1080 and MCF-7 with IC50s of 52 and 8.2 μM respectively.
    Antiproliferative agent-40
  • HY-121247
    Bromotetrandrine
    Bromotetrandrine is a potent inhibitor of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR). Bromotetrandrine shows significant MDR reversal activity in vitro and in vivo, which may be related to the inhibition of P-gp overexpression and the increase in intracellular accumulation of anticancer agents. Bromotetrandrine is a brominated derivative of tetrandrine, which is promising for MDR modulator for tumor assessment.
    Bromotetrandrine
  • HY-129406
    AF 698
    AF 698 is a phthalate derivative of Apovincamine (HY-135743) that can be used as a peripheral vasodilator with selective vasomotor effects on cerebral microvascular circulation. AF 698 has better vasodilator effect than Vincamine (HY-B1021), but there is no significant difference in the protective effect of the two drugs against hypobaric hypoxia-induced lethality in mice.
    AF 698
  • HY-W726084
    1,2:5,6-Di-O-isopropylidene-L-chiro-inositol
    1,2:5,6-Di-O-isopropylidene-L-chiro-inositol is a derivative of inositol.
    1,2:5,6-Di-O-isopropylidene-L-chiro-inositol
  • HY-168014
    5-Methylthio DMT
    5-Methylthio DMT (5-OMe DMT) is a tryptamine with psychoactivity.
    5-Methylthio DMT
  • HY-139090
    3-Oxobetulin acetate
    3-Oxobetulin acetate (28-O-Acetyl-3-Oxobetulin; 3-oxo-28-O-Acetylbetulin) is a derivative of betulin (HY-N0083), a cholesterol biosynthesis inhibitor. 3-Oxobetulin acetate inhibits the growth of P388 murine lymphocytic leukemia cells (EC50=0.12 μg/mL) and human MCF-7 breast cancer, SF-268 CNS cancer, H460 lung cancer, and KM20L2 colon cancer cells (GI50s=8, 10.6, 5.2, and 12.7 μg/mL), but not BxPC-3 pancreatic cancer cells or DU145 prostate cancer cells (GI50s=>10 μg/mL for both). 3-Oxobetulin acetate inhibits the replication of X4-tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblastoid cells (IC50=13.4 μM). 3-Oxobetulin acetate is also effective against Listeria donovani amastigotes.
    3-Oxobetulin acetate
  • HY-129672
    Thelenotoside B
    Thelenotoside B (25-Dihydrostichorrenoside E) shows strong cytotoxicities against five cancer cell lines as HepG2, KB, LNCaP, MCF7 and SK-Mel2 with the IC50 values from 0.95 ± 0.08 to 1.90 ± 0.13 μM. Thelenotoside B is a triterpene tetraglycoside.
    Thelenotoside B