2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glyoxalase (GLO)

Glyoxalase (GLO)

The glyoxalase system is critical for the detoxification of advanced glycation end-products (AGEs). AGEs are toxic compounds resulting from the non-enzymatic modification of biomolecules by sugars or their metabolites through a process called glycation. AGEs have adverse effects on many tissues, playing a pathogenic role in the progression of molecular and cellular aging.

The glyoxalase system consists of two cooperating enzymes named Glyoxalase 1 (Glo1) and Glyoxalase 2 (Glo2). Glo1 converts a non-enzymatically formed hemithioacetal, the adduct between an intracellular thiol such as glutathione (GSH) and a metabolically produced α-ketoaldehyde such as MG, into a thioester product . In the case of MG and GSH, S-D-lactoylglutathione is the product. Glo2 hydrolyzes this thioester into D-lactate and regenerates the intracellular thiol GSH. Glo1 and Glo2 work in tandem to convert cytoxic MG into D-lactate.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-136684
    BrBzGCp2
    		Inhibitor 98.68%
    BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity.
    BrBzGCp2
  • HY-15167A
    Glyoxalase I inhibitor free base
    		Inhibitor 98.52%
    Glyoxalase I inhibitor (free base) is a potent Glyoxalase I (GLO1) inhibitor, candidate for anticancer agents.
    Glyoxalase I inhibitor free base
  • HY-W009177
    S-Methylglutathione
    		Inhibitor ≥99.0%
    S-Methylglutathione is an S-substitued glutathione and a stronger nucleophile than GSH. S-Methylglutathione has inhibitory effect on glyoxalase 1.
    S-Methylglutathione
  • HY-147648
    Glyoxalase I inhibitor 6
    		Inhibitor 99.26%
    Glyoxalase I inhibitor 6 (Compound 9j) is a glyoxalase I (Glo-I) inhibitor with an IC50 of 1.13 μM. Glyoxalase I inhibitor 6 can be used as anticancer agent with low toxicity.
    Glyoxalase I inhibitor 6
  • HY-146655
    Glyoxalase I inhibitor 3
    		Inhibitor 98.06%
    Glyoxalase I inhibitor 3 (compound 22g) is a potent glyoxalase I (GLO1) inhibitor with an IC50 of 0.011 µM. Glyoxalase I inhibitor 3 has the potential for the research of depression and anxiety.
    Glyoxalase I inhibitor 3
  • HY-147647
    Glyoxalase I inhibitor 5
    		98.07%
    Glyoxalase I inhibitor 5 (Compound 9h) is a glyoxalase I (Glo-I) inhibitor with an IC50 of 1.28 μM. Glyoxalase I inhibitor 5 can be used as anticancer agent.
    Glyoxalase I inhibitor 5
  • HY-15167
    Glyoxalase I inhibitor
    		Inhibitor ≥98.0%
    Glyoxalase I inhibitor is a potent Glyoxalase I inhibitor, candidate for anticancer agents.
    Glyoxalase I inhibitor
  • HY-115915
    TS010
    		Inhibitor
    TS010 is a potent inhibitor of GLO-I with IC50 of 0.57 μM. TS010 has the potential for the research of cancer disease.
    TS010
  • HY-147649
    Glyoxalase I inhibitor 7
    		Inhibitor
    Glyoxalase I inhibitor 7 (Compound 6) is a glyoxalase I (Glo-I) inhibitor with an IC50 of 3.65 μM. Glyoxalase I inhibitor 7 can be used as anticancer agent.
    Glyoxalase I inhibitor 7
  • HY-146656S
    S-Sulfo-DL-cysteine-2,3,3-d3
    S-Sulfo-DL-cysteine-2,3,3-d3 is the deuterium labeled S-Sulfo-DL-cysteine-2,3,3.
    S-Sulfo-DL-cysteine-2,3,3-d<sub>3</sub>
  • HY-146656
    Glyoxalase I inhibitor 4
    		Inhibitor
    Glyoxalase I inhibitor 4 (compound 14) is a potent glyoxalase I inhibitor with an Ki of 10 nM.
    Glyoxalase I inhibitor 4
  • HY-146653
    Glyoxalase I inhibitor 1
    		Inhibitor
    Glyoxalase I inhibitor 1 (compound 23) is a potent glyoxalase I (GLO1) inhibitor with an IC50 of 26 nM. Glyoxalase I inhibitor 1 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Glyoxalase I inhibitor 1
  • HY-146654
    Glyoxalase I inhibitor 2
    		Inhibitor
    Glyoxalase I inhibitor 2 (compound 26) is a potent glyoxalase I (GLO1) inhibitor with an IC50 of 0.5 µM. Glyoxalase I inhibitor 2 has the potential for the research of depression and anxiety.
    Glyoxalase I inhibitor 2
  • HY-P4277
    N,S-Bis-Fmoc-Glutathione
    		Inhibitor
    N,S-Bis-Fmoc-Glutathione is a potent glyoxalase II inhibitor with a Ki value of 0.32 mM.
    N,S-Bis-Fmoc-Glutathione
  • HY-124824
    Methyl gerfelin
    		Inhibitor
    Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA). Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class.
    Methyl gerfelin
  • HY-148216
    HBPC–GSH
    		Inhibitor
    HBPC-GSH is a glyoxalase (Glo) inhibitor (cGloI IC50=0.6 μM; cGloII IC50=1.6 μM), a glutathione derivative. HBPC-GSH can be used in antimalarial research.
    HBPC–GSH
  • HY-146657
    4BAB
    		Inhibitor
    4BAB (compound 29) is an irreversible glyoxalase I (GLO1) inhibitor. 4BAB has anticancer effects.
    4BAB
Cat. No. Product Name / Synonyms Application Reactivity