Glyoxalase I inhibitor

Name: Glyoxalase I inhibitor
Brand: MedChemExpress
SKU: HY-15167
Rating: 5.0 (4 reviews)

Cat. No.: HY-15167: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Glyoxalase I inhibitor is a potent Glyoxalase I inhibitor, candidate for anticancer agents.

For research use only. We do not sell to patients.

Glyoxalase I inhibitor Chemical Structure

CAS No. : 221174-33-0

Size	Price	Stock	Quantity
1 mg	USD 168	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 4 publication(s) in Google Scholar

Other Forms of Glyoxalase I inhibitor:

Glyoxalase I inhibitor free base In-stock

4 Publications Citing Use of MCE Glyoxalase I inhibitor

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Biological Activity
Purity & Documentation
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Description

Glyoxalase I inhibitor is a potent Glyoxalase I inhibitor, candidate for anticancer agents.

Molecular Weight

613.91

Formula

C₂₁H₃₀BrClN₄O₈S

CAS No.

221174-33-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

BrC1=CC=C(N(O)C(SC[C@H](NC(CC[C@H](N)C(OCC)=O)=O)C(NCC(OCC)=O)=O)=O)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 37 mg/mL (60.27 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6289 mL	8.1445 mL	16.2890 mL
5 mM	0.3258 mL	1.6289 mL	3.2578 mL
10 mM	0.1629 mL	0.8145 mL	1.6289 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (246 KB) SDS (252 KB)

COA (249 KB) HNMR (237 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6289 mL	8.1445 mL	16.2890 mL	40.7226 mL
	5 mM	0.3258 mL	1.6289 mL	3.2578 mL	8.1445 mL
	10 mM	0.1629 mL	0.8145 mL	1.6289 mL	4.0723 mL
	15 mM	0.1086 mL	0.5430 mL	1.0859 mL	2.7148 mL
	20 mM	0.0814 mL	0.4072 mL	0.8145 mL	2.0361 mL
	25 mM	0.0652 mL	0.3258 mL	0.6516 mL	1.6289 mL
	30 mM	0.0543 mL	0.2715 mL	0.5430 mL	1.3574 mL
	40 mM	0.0407 mL	0.2036 mL	0.4072 mL	1.0181 mL
	50 mM	0.0326 mL	0.1629 mL	0.3258 mL	0.8145 mL
	60 mM	0.0271 mL	0.1357 mL	0.2715 mL	0.6787 mL