2. Signaling Pathways
  3. GPCR/G Protein
  4. Hydroxycarboxylic Acid Receptor (HCAR)
  5. Hydroxycarboxylic Acid Receptor (HCAR) Agonist

Hydroxycarboxylic Acid Receptor (HCAR) Agonist

Hydroxycarboxylic Acid Receptor (HCAR) Agonists (3):

Cat. No. Product Name Effect Purity
  • HY-100976
    LUF6283
    		Agonist ≥99.0%
    LUF6283 is a potent and orally active HCA(2) partial agonist, with a Ki of 0.55 µM. LUF6283 can achieve the beneficial lipid lowering effect of niacin without producing the unwanted cutaneous flushing side effect.
  • HY-156025
    HCAR2 agonist 1
    		Agonist 99.11%
    HCAR2 agonist 1 (Compound 9n) is a Gi protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the Gi protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis.
  • HY-141434
    5-OxoETE methyl ester
    		Agonist
    5-OxoETE methyl ester is the agonist for oxoeicosanoid receptor 1 (OXER1). 5-OxoETE methyl ester binds to OXER1, and activates downstream signaling pathways β-arrestin recruitment with an EC50 of 1.54 µM.