2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. iGluR

iGluR

Ionotropic glutamate receptors

iGluR

Related Products

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iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR Isoform Specific Products:

iGluR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13059A
    SDZ 220-581 Ammonium salt
    		Antagonist
    SDZ 220-581 Ammonium salt is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7.
    SDZ 220-581 Ammonium salt
  • HY-B0122S1
    Topiramate-13C
    		Antagonist
    Topiramate-13C (McN 4853-13C) is 13C labeled Topiramate. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
    Topiramate-<sup>13</sup>C<sub>
  • HY-148708
    Oleoyl-D-lysine
    		Inhibitor
    Oleoyl-D-lysine is a selective Glycine Transporter-2 (GlyT2) inhibitor based on lipid. Oleoyl-D-lysine reverses neuropathic pain in mice，shows antidrowsiness effect on chronic neuropathic pain. Oleoyl-D-lysine is safe and effective without respiratory depression.
    Oleoyl-D-lysine
  • HY-169806
    Methalthiazide
    Methalthiazide enhances the activity of natural stimulators of AMPA receptors and can be used in the study of schizophrenia.
    Methalthiazide
  • HY-120811
    PF-04701475
    		Agonist
    PF-04701475 is a potent AMPA receptor potentiator with an EC50 of 123 nM. PF-04701475 can be used for the study of neurological disorders.
    PF-04701475
  • HY-W922811
    DL-Willardiine
    		Antagonist
    DL-Willardiine is an AMPA antagonist with an IC50 of 2 μM. DL-Willardiine can be utilized in psychotropic cccccc research.
    DL-Willardiine
  • HY-160931
    NMDA receptor modulator 8
    		Modulator
    NMDA receptor modulator 8 (Compound 3-6) is a modulator for NMDA receptor, with 50%-100% potentiation of NMDA receptor at 10 μM.
    NMDA receptor modulator 8
  • HY-17555R
    Meclofenoxate (hydrochloride) (Standard)
    		Activator
    Meclofenoxate (hydrochloride) (Standard) is the analytical standard of Meclofenoxate (hydrochloride). This product is intended for research and analytical applications. Meclofenoxate hydrochloride is an ester synthesized from DMAE and pCPA, which has the activity of stimulating memory and improving cognition.
    Meclofenoxate (hydrochloride) (Standard)
  • HY-17553R
    Coluracetam (Standard)
    		Activator
    Coluracetam (Standard) is the analytical standard of Coluracetam. This product is intended for research and analytical applications. Coluracetam (MKC-231) is a new choline absorption enhancer.
    Coluracetam (Standard)
  • HY-104020B
    Philanthotoxin 74 diTFA
    		Antagonist
    Philanthotoxin 74 (PhTx 74) diTFA is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively.
    Philanthotoxin 74 diTFA
  • HY-B1283S
    Mephenesin-d3
    		Antagonist
    Mephenesin-d3 is deuterium labeled Mephenesin. Mephenesin is an NMDA receptor antagonist. Mephenesin is also a central muscle relaxant with antianxiety, muscle-paralyzing and anticonvulsant effects. Mephenesin acts directly on the skeletal muscle fibres to produce skeletal muscle relaxation. Mephenesin is promising for research of spasticity or painful muscle spasm.
    Mephenesin-d<sub>3</sub>
  • HY-15410A
    Gacyclidine hydrochloride
    		Antagonist
    Gacyclidine hydrochloride, a non competitive N-methyl-D-aspartate (NMDA) antagonist, can be used in the study of spinal cord injuries.
    Gacyclidine hydrochloride
  • HY-17456R
    Omberacetam (Standard)
    		Agonist
    Omberacetam (Standard) is the analytical standard of Omberacetam. This product is intended for research and analytical applications. Omberacetam (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.
    Omberacetam (Standard)
  • HY-B1283R
    Mephenesin (Standard)
    		Antagonist
    Mephenesin (Standard) is the analytical standard of Mephenesin. This product is intended for research and analytical applications. Mephenesin is an NMDA receptor antagonist and Mephenesin is a central muscle relaxant.
    Mephenesin (Standard)
  • HY-B0122SS1
    Topiramate-13C6-1
    		Antagonist
    Topiramate-13C6-1 (McN 4853-13C6-1; RWJ 17021-13C6-1) is 13C-labeled Topiramate (HY-B0122).
    Topiramate-<sup>13</sup>C<sub>6</sub>-1
  • HY-14608S12
    L-Glutamic acid-14C
    		Agonist
    L-Glutamic acid-14C is L-Glutamic acid (HY-14608) labeled with the radioactive isotope carbon-14. L-Glutamic acid is an excitatory amino acid neurotransmitter and an agonist for all subtypes of glutamate receptors (metabotropic, NMDA, and AMPA). L-Glutamic acid acts as an agonist in the release of DA from dopaminergic nerve terminals and can be used in the study of neurological diseases.
    L-Glutamic acid-14C
  • HY-17001R
    Flupirtine (Maleate) (Standard)
    		Antagonist
    Flupirtine (Maleate) (Standard) is the analytical standard of Flupirtine (Maleate). This product is intended for research and analytical applications. Flupirtine Maleate is a brain penetrant, and orally bioavailable, non-opioid and centrally acting analgesic agent. Flupirtine Maleate is an indirect N-methyl-D-aspartate receptor (NMDAR) antagonist. Neuroprotective properties.
    Flupirtine (Maleate) (Standard)
  • HY-123904
    UoS12258
    		Activator 99.86%
    UoS12258 is a selective positive allosteric modulator of AMPA receptor. UoS12258 enhances AMPA receptor‐mediated synaptic transmission. UoS12258 improves performance in cognition rat models, including Scopolamine (HY-N0296)‐impaired rats and water maze learning and retention in aged rats.
    UoS12258
  • HY-P1391
    ZIP(Scrambled)
    		Control
    ZIP(Scrambled) is a scrambled control peptide for zeta inhibitory peptide (ZIP).
    ZIP(Scrambled)
  • HY-B0122R
    Topiramate (Standard)
    		Antagonist
    Topiramate (Standard) is the analytical standard of Topiramate. This product is intended for research and analytical applications. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
    Topiramate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
iGluR Isoform Comparison

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