2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. mAChR
  5. mAChR1 Isoform
  6. mAChR1 Inhibitor

mAChR1 Inhibitor

mAChR1 Inhibitors (9):

Cat. No. Product Name Effect Purity
  • HY-B1339
    Dicyclomine hydrochloride
    		Inhibitor ≥98.0%
    Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo.
  • HY-13204
    Biperiden hydrochloride
    		Inhibitor 99.90%
    Biperiden (KL 373) hydrochloride is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden hydrochloride has the potential for the research of Parkinson's disease and other related psychiatric disorders.
  • HY-13204S2
    rel-Biperiden EP impurity A-d5
    		Inhibitor
    rel-Biperiden EP impurity A-d5 is deuterium labeled Biperiden (hydrochloride).
  • HY-13204S3
    rel-Biperiden EP impurity B-d5
    		Inhibitor
    rel-Biperiden EP impurity B-d5 is deuterium labeled Biperiden (hydrochloride).
  • HY-13204S
    Biperiden-d5 hydrochloride
    		Inhibitor
    Biperiden-d5 (hydrochloride) is the deuterium labeled Biperiden hydrochloride. Biperiden (KL 373) hydrochloride is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker.
  • HY-101653
    MHP 133
    		Inhibitor
    MHP 133 is a agent with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.
  • HY-13204S1
    rel-Biperiden-d5
    		Inhibitor
    rel-Biperiden-d5 is deuterium labeled Biperiden (hydrochloride).
  • HY-167849
    Sofpironium tosylate
    		Inhibitor
    Sofpironium (BBI 4000) tosylate is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium tosylate reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium tosylate also has a high afnity for the M1, M2, M4 and M5 subtypes.
  • HY-B1277S
    Trihexyphenidyl-d5 hydrochloride
    		Inhibitor
    Trihexyphenidyl-d5 (hydrochloride) is deuterium labeled Trihexyphenidyl (hydrochloride).