Biperiden hydrochloride (Synonyms: KL 373 hydrochloride)

Cat. No.: HY-13204 Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

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Biperiden (KL 373) hydrochloride is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden hydrochloride has the potential for the research of Parkinson's disease and other related psychiatric disorders.

For research use only. We do not sell to patients.

Biperiden hydrochloride Chemical Structure

CAS No. : 1235-82-1

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 110	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 110	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of Biperiden hydrochloride:

Biperiden-d₅ hydrochloride Get quote
rel-Biperiden-d₅ Get quote
rel-Biperiden EP impurity A-d₅ Get quote
rel-Biperiden EP impurity B-d₅ Get quote
Biperiden Get quote
Biperiden lactate Get quote
Biperiden hydrochloride (Standard) Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Biperiden hydrochloride (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	Panc-1, Panc-2 and BxPC3 human pancreatic ductal adenocarcinoma cells
Concentration:	29.6 μg/mL
Incubation Time:	72 hours
Result:	Inhibited cell proliferation at 72 hours significantly by reducing nuclear c-Rel translocation.

In Vivo

Biperiden hydrochloride (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells^[1].
Biperiden hydrochloride (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; everyday; 3 weeks
Result:	Tumor size reduced by 83%.

Animal Model:	Male Wistar rats (200-250 g)^[2]
Dosage:	8 mg/kg
Administration:	Intraperitoneal injection; every 8 hours; 10 days
Result:	Reduced late seizures by about three times with no affecting emotional memory damage.

Clinical Trial

Molecular Weight

347.92

Formula

C₂₁H₃₀ClNO

CAS No.

1235-82-1

Appearance

Solid

Color

White to off-white

SMILES

OC(C1CC2C=CC1C2)(CCN3CCCCC3)C4=CC=CC=C4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 3.75 mg/mL (10.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8742 mL	14.3711 mL	28.7422 mL
5 mM	0.5748 mL	2.8742 mL	5.7484 mL
10 mM	0.2874 mL	1.4371 mL	2.8742 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (247 KB) HNMR (282 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Leonie Konczalla，et al. Biperiden and mepazine effectively inhibit MALT1 activity and tumor growth in pancreatic cancer. Int J Cancer. 2020 Mar 15;146(6):1618-1630. [Content Brief]

[2]. Simone Bittencourt, et al. Modification of the natural progression of epileptogenesis by means of biperiden in the pilocarpine model of epilepsy. Epilepsy Res. 2017 Dec;138:88-97. doi: 10.1016/j.eplepsyres.2017.10.019. Epub 2017 Oct 29. [Content Brief]

[3]. Pehl C, et al. Effects of two anticholinergic drugs, trospium chloride and biperiden, on motility and evoked potentials of the oesophagus. Aliment Pharmacol Ther. 1998 Oct;12(10) [Content Brief]

[4]. Kornhuber J, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8) [Content Brief]

[5]. Myhrer T, et al. Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats. Pharmacol Biochem Behav. 2008 Jun;89(4):633-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8742 mL	14.3711 mL	28.7422 mL	71.8556 mL
	5 mM	0.5748 mL	2.8742 mL	5.7484 mL	14.3711 mL
	10 mM	0.2874 mL	1.4371 mL	2.8742 mL	7.1856 mL

Biperiden hydrochloride Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biperiden1235-82-1KL 373KL373KL-373mAChRMuscarinic acetylcholine receptorMuscarinic receptor antagonistParkinson's diseaseAnticholinergicInhibitorinhibitorinhibit

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