2. Signaling Pathways
  3. PROTAC
  4. Molecular Glues

Molecular Glues

Molecular Glues

Related Products

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Protein degradation agents based on the ubiquitin-proteasome pathway include a part of molecular glues. Molecular glues are a class of small molecule compounds that can induce or stabilize the interaction between proteins. If one of the protein is ubiquitin ligase, molecular glue can cause another protein to undergo ubiquitin modification and degradation through the proteasome pathway, which is similar to PROTAC. However, these molecules are classified as ligand for E3 ligase as functional molecules in subsequent classification. Older drugs, thalidomide, lenalidomide, and pomalidomide, together with CC-90009 and CC-92480 reported later all belong to this category.

Molecular Glues Related Products (160):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0579S1
    Cyclosporin A-d3 222295-76-3
    Cyclosporin A-d3 is the d3-labeled Cyclosporin A (HY-B0579)[1].
    Cyclosporin A-d<sub>3</sub>
  • HY-150641
    CDK-IN-9 3031561-92-6
    CDK-IN-9 (compound 24) is a potent CDK inhibitor, also as a molecular glue inducing an interaction between CDK12 and DDB1, with an IC50 values of 4 nM for CDK2/E. CDK-IN-9 leads to polyubiquitination of cyclin K and its subsequent degradation. CDK-IN-9 induce apoptosis through dephosphorylation of retinoblastoma protein and RNA polymerase II.
    CDK-IN-9
  • HY-161767
    JWJ-01-306
    JWJ-01-306 is a molecular glue that targets the C2H2 zinc finger transcription factor ZBTB11. JWJ-01-306 degrades ZBTB11, reduces the oxidative phosphorylation (OXPHOS) and tricarboxylic acid (TCA) cycle, and inhibits the proliferation of KAS-resistant PDAC cells. JWJ-01-306 exhibits good pharmacokinetic characteristics in mouse model.
    JWJ-01-306
  • HY-168646
    SJ46411-Br
    SJ46411-Br is one of CRL2KLHDC2 targeting Ligands for E3 Ligase. SJ46411-Br can bind to KLHDC2 to form a complex to promote cooperative homologous selective ternary complex formation. SJ46411-Br can be coupled to BET ligand JQ1 (HY-13030) through PROTAC linker to synthesize corresponding PROTACs.
    SJ46411-Br
  • HY-168624
    VAV1 degrader-2 3050683-29-6
    VAV1 degrader-2 (Example 176) is a molecular glue degrader based on targeting VAV 1 with a DC50 of 4.41 nM. VAV1 degrader-2 can be used in the study of inflammatory and autoimmune diseases.
    VAV1 degrader-2
  • HY-163812
    ER degrader 9 3023359-75-0
    ER degrader 9 (compound 1), a bifunctional molecular glue, is a potent estrogen receptor (ER) degrader with a DC50 of ≤10 nM in MCF-7 cells. ER degrader 9 can be used for the research of breast cancer.
    ER degrader 9
  • HY-162534
    GSPT1 degrader-5 3034764-38-7
    GSPT1 degrader-5 (4) is a GSPT1 molecule glue (DC50 of 144 nM).
    GSPT1 degrader-5
  • HY-10984S3
    Pomalidomide-15N,13C5
    Pomalidomide-15N,13C5 is 15N and 13C labeled Pomalidomide (HY-10984). Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.
    Pomalidomide-<sup>15</sup>N,<sup>13</sup>C<sub>5</sub>
  • HY-161236
    KRAS ligand 4
    KRAS ligand 4 (compound 2) is a bifunctional molecular glue degrader based on SOS1. KRAS ligand 4 reduces downstream signaling markers pERK and pS6 and displays anti-additional activity in cells with multiple KRAS mutations.
    KRAS ligand 4
  • HY-106638R
    Voclosporin (Standard) 515814-01-4
    Voclosporin (Standard) is the analytical standard of Voclosporin. This product is intended for research and analytical applications. Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor.
    Voclosporin (Standard)
  • HY-169081
    QS-57
    QS-57 is a PROTAC targeting BRD4. QS-57 can be used as a 14-3-3 molecular glue. (Red: EN171 (HY-W1005067), black: (2-Aminoethyl) carbamic acid (HY-W398806), Blue: JQ-1 (carboxylic acid) (HY-78695)).
    QS-57
  • HY-10984R
    Pomalidomide (Standard) 19171-19-8
    Pomalidomide (Standard) is the analytical standard of Pomalidomide. This product is intended for research and analytical applications. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.
    Pomalidomide (Standard)
  • HY-10984S4
    Pomalidomide-13C5 1416575-79-5
    Pomalidomide-13C5 (CC-4047-13C5) is 13C labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.
    Pomalidomide-<sup>13</sup>C<sub>5</sub>
  • HY-106638S
    Voclosporin-d4
    Voclosporin-d4 (ISAtx-247-d4) is deuterium labeled Voclosporin. Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor.
    Voclosporin-d<sub>4</sub>
  • HY-A0003S3
    Lenalidomide-d4 1130061-52-7
    Lenalidomide-d4 (CC-5013-d4) is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.
    Lenalidomide-d<sub>4</sub>
  • HY-W039943
    Acetyl-cyclosporin A aldehyde 121584-52-9
    Acetyl-cyclosporin A aldehyde is an acetylated Cyclosporin A (HY-B0579) derivative with a reducing aldehyde group. Cyclosporin A is a potent calmodulin inhibitor and cyclophilin binder that can target the nuclear translocation of NF-AT and cause mitochondrial damage.
    Acetyl-cyclosporin A aldehyde
  • HY-164891
    EM12-FS 2839138-44-0
    EM12-FS is a cereblon (CRBN) ligand that binds CRBN at His353 and a molecular glue degrader of NTAQ1. EM12-FS has a human plasma half-life of 196 min.
    EM12-FS
  • HY-135643
    Sanglifehrin A 187148-13-6
    Sanglifehrin A is an immunosuppressive macrocyclic natural product. Sanglifehrin A promots Cyclophilin A complexation with inosine-5'-monophosphate dehydrogenase 2 (IMPDH2).
    Sanglifehrin A
  • HY-W1005067
    EN171 2191110-79-7
    EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol.
    EN171
  • HY-160531
    IKZF1-degrader-1 2915586-02-4
    IKZF1-degrader-1 (Compound 9-B) is a IKZF1 molecular glue degrader with the DC50 value of 0.134 nM. IKZF1-degrader-1 can be used to degrader tumors.
    IKZF1-degrader-1