2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. NADPH Oxidase

NADPH Oxidase

NOX

NADPH Oxidase

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NADPH-oxidase (NOX) is a highly regulated dynamic complex comprising membrane and cytosolic proteins and is the major source of nonmitochondrial cellular reactive oxygen species (ROS). The ROS generated by NADPH oxidases have crucial roles in various physiological processes, including innate immunity, modulation of redox-dependent signalling cascades, and as cofactors in the production of hormones.

NOX enzymes are a family of transmembrane proteins comprising seven members (NOX1-NOX5 and DUOX1 and DUOX2), each with a specific tissue distribution and activation mechanism. They catalyze the reduction of molecular oxygen to superoxide anion, which in turn reacts quickly to generate other ROS, such as hydrogen peroxide. Although basic NOX activity is crucial for normal physiology, overshooting activity of NOX enzymes leads to disease. NADPH oxidases are increasingly recognized as interesting drug targets.

NADPH Oxidase Isoform Specific Products:

NADPH Oxidase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS09457
    NOX1 Human Pre-designed siRNA Set A
    		Inhibitor

    NOX1 Human Pre-designed siRNA Set A contains three designed siRNAs for NOX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    NOX1 Human Pre-designed siRNA Set A
    NOX1 Human Pre-designed siRNA Set A
  • HY-RS09462
    Nox4 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Nox4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nox4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Nox4 Mouse Pre-designed siRNA Set A
    Nox4 Mouse Pre-designed siRNA Set A
  • HY-RS09459
    Nox1 Rat Pre-designed siRNA Set A
    		Inhibitor

    Nox1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nox1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Nox1 Rat Pre-designed siRNA Set A
    Nox1 Rat Pre-designed siRNA Set A
  • HY-W614507
    Dihydronicotinamide riboside
    		Activator
    Dihydronicotinamide riboside is a potent NAD+ concentration enhancer. Dihydronicotinamide riboside can be metabolized into NMNH by ATP-dependent kinase[1]< sup>.
    Dihydronicotinamide riboside
  • HY-B0203BS2
    (Rac)-Nebivolol-d2,15N
    		Inhibitor
    (Rac)-Nebivolol-d2,15N is 15N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity.
    (Rac)-Nebivolol-d<sub>2</sub>,<sup>15</sup>N
  • HY-156425
    NOX2-IN-2
    		Inhibitor
    NOX2-IN-2 (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. NOX2-IN-2 inhibits ROS production derived from NOX2 in cells.
    NOX2-IN-2
  • HY-170540
    NOX4-IN-1
    		Inhibitor
    NOX4-IN-1 (Compound 14m) is the inhibitor for NADPH oxidase 4 (NOX4), and blocks the generation of ROS. NOX4-IN-1 inhibits TGF-β1/Smad signaling pathway, decreases the expression of fibrosis-related proteins. NOX4-IN-1 inhibits the cell migration of NRK-49F.
    NOX4-IN-1
  • HY-RS09458
    Nox1 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Nox1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nox1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Nox1 Mouse Pre-designed siRNA Set A
    Nox1 Mouse Pre-designed siRNA Set A
  • HY-P5329
    r8-Gly-Noxa A BH3
    r8-Gly-Noxa A BH3 is a biological active peptide. (This cell permeable peptide is derived from the BH3 domain (a death domain) of Noxa A, amino acid residues 17 to 36. Eight D-Arginine residues and a Glycine linker residue are added to the amino terminal of the peptide.)
    r8-Gly-Noxa A BH3
  • HY-P5330
    Noxa B BH3
    Noxa B BH3 is a biological active peptide. (BH3 domain of Noxa protein)
    Noxa B BH3
  • HY-B0530A
    Azacyclonol hydrochloride
    		Inhibitor
    Azacyclonol (γ-pipradol) hydrochloride is a compound with promising anticancer activity, showing effectiveness in inhibiting NOX-derived ROS in A549 human lung cancer cells. Azacyclonol hydrochloride exhibits enhanced proliferation inhibition against androgen-refractory cancer cell lines, specifically DU145 and PC-3. Azacyclonol hydrochloride demonstrates antitumor activity in DU145-xenografted chorioallantoic membrane tumor models. Azacyclonol hydrochloride also acts as a ligand for the M3 muscarinic acetylcholine receptor, which is overexpressed in ARPC. Azacyclonol hydrochloride effectively blocks carbachol-induced proliferation and NOX activity in DU145 cells. Azacyclonol hydrochloride can also be utilized for the treatment of chronic schizophrenia.
    Azacyclonol hydrochloride
  • HY-157445
    CBR1-IN-3
    CBR1-IN-3 (compound 13h) is a potent inhibitor of carbonyl reductase 1 (CBR1), with IC50 value of 0.034 μM.
    CBR1-IN-3
  • HY-P1908
    sgp91 ds-tat Peptide 2, scrambled
    		Inhibitor
    sgp91 ds-tat Peptide 2, scrambled is a scrambled sequence of NADPH oxidase inhibitor gp91 ds-tat peptide.
    sgp91 ds-tat Peptide 2, scrambled
  • HY-121097
    Diapocynin
    		Inhibitor
    Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active NADPH oxidase inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities.
    Diapocynin
  • HY-153978
    GLX481369
    		Inhibitor
    GLX481369 is a redox active substance. GLX481369 is a Nox4 inhibitor. GLX481369 has antioxidant effects.
    GLX481369
  • HY-P5384
    sgp91 ds-tat
    		Inhibitor
    sgp91 ds-tat is a biological active peptide. (This is a scrambled control peptide for gp91 ds-tat.)
    sgp91 ds-tat
  • HY-RS09463
    Nox4 Rat Pre-designed siRNA Set A
    		Inhibitor

    Nox4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nox4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Nox4 Rat Pre-designed siRNA Set A
    Nox4 Rat Pre-designed siRNA Set A
  • HY-156424
    NOX2-IN-1
    		Inhibitor
    NOX2-IN-1 (compound 10) is an inhibitor of nicotinamide adenine dinucleotide phosphate oxidase isoform 2 (NOX2). NOX2-IN-1 targets the p47phox−p22phox protein−protein interaction with favorable binding affinities and cellular activities.
    NOX2-IN-1
  • HY-N0088R
    Apocynin (Standard)
    		Inhibitor
    Apocynin (Standard) is the analytical standard of Apocynin. This product is intended for research and analytical applications. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model. Apocynin can also be used for cancer research. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass.
    Apocynin (Standard)
  • HY-128004
    ML171 analog 1
    		Inhibitor
    ML171 analog 1 (Crop ID: SR-03000000698-1 SID: 57287906) is a NOX1 inhibitor. ML171 analog 1 can be used in cancer research.
    ML171 analog 1
Cat. No. Product Name / Synonyms Application Reactivity
NADPH Oxidase Isoform Comparison

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