2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. NADPH Oxidase
  5. NADPH Oxidase Isoform

NADPH Oxidase

 

NADPH Oxidase Related Products (21):

Cat. No. Product Name Effect Purity
  • HY-100965
    Diphenyleneiodonium chloride
    		Inhibitor 99.91%
    Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.
  • HY-N0088
    Apocynin
    		Inhibitor 99.96%
    Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model. Apocynin can also be used for cancer research. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass.
  • HY-12804
    VAS2870
    		Inhibitor 98.45%
    VAS2870 is a NADPH oxidase (NOX) inhibitor.
  • HY-101499A
    GKT136901 hydrochloride
    		Inhibitor 99.90%
    GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity.
  • HY-129997
    Luteolinidin chloride
    		Inhibitor 99.14%
    Luteolinidin chloride is a deoxyanthocyanidin isolated from the plant Sorghum bicolor with antioxidant activity. Luteolinidin chloride is a potent CD38 inhibitor (Ki=11.4 μM) and protects the heart from ischemia/reperfusion injury by preserving endothelial nitric oxide synthase (eNOS) function and preventing endothelial dysfunction. Luteolinidin chloride is also a competitive inhibitor of tyrosinase (IC50=3.7 μM) and blocks the production of melanin.
  • HY-N0088R
    Apocynin (Standard)
    		Inhibitor
    Apocynin (Standard) is the analytical standard of Apocynin. This product is intended for research and analytical applications. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model. Apocynin can also be used for cancer research. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass.
  • HY-156425A
    NOX2-IN-2 diTFA
    		Inhibitor
    NOX2-IN-2 diTFA (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. NOX2-IN-2 diTFA inhibits ROS production derived from NOX2 in cells.
  • HY-119576
    Phox-I2
    		Inhibitor 99.52%
    Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production.
  • HY-P5381
    gp91 ds-tat
    		Inhibitor 98.27%
    gp91 ds-tat is a biological active peptide. (NADPH oxidase assembly peptide inhibitor)
  • HY-P5328
    Noxa A BH3
    		99.61%
    Noxa A BH3 is a biological active peptide. (BH3 domain of Noxa protein)
  • HY-153977
    GLX481304
    		Inhibitor 99.90%
    GLX481304 is a specific inhibitor of Nox-2 and -4, with IC50s of 1.25 μM. GLX481304 suppresses ROS production in isolated mouse cardiomyocytes and improves cardiomyocyte contractility. GLX481304 can be used for research of ischemic injury to the heart.
  • HY-RS09461
    NOX4 Human Pre-designed siRNA Set A
    		Inhibitor

    NOX4 Human Pre-designed siRNA Set A contains three designed siRNAs for NOX4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-111447
    VAS 3947
    		Inhibitor 99.59%
    VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.
  • HY-W549903
    p67phox-IN-1
    		Inhibitor
    p67phox-IN-1 (Formula IIIa Compound) is an inhibitor targeting the interaction between Rac GTPase and p67phox protein.
  • HY-B0203BS2
    (Rac)-Nebivolol-d2,15N
    		Inhibitor
    (Rac)-Nebivolol-d2,15N is 15N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity.
  • HY-156425
    NOX2-IN-2
    		Inhibitor
    NOX2-IN-2 (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. NOX2-IN-2 inhibits ROS production derived from NOX2 in cells.
  • HY-P5329
    r8-Gly-Noxa A BH3
    r8-Gly-Noxa A BH3 is a biological active peptide. (This cell permeable peptide is derived from the BH3 domain (a death domain) of Noxa A, amino acid residues 17 to 36. Eight D-Arginine residues and a Glycine linker residue are added to the amino terminal of the peptide.)
  • HY-P5330
    Noxa B BH3
    Noxa B BH3 is a biological active peptide. (BH3 domain of Noxa protein)
  • HY-121097
    Diapocynin
    		Inhibitor
    Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active NADPH oxidase inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities.
  • HY-153978
    GLX481369
    		Inhibitor
    GLX481369 is a redox active substance. GLX481369 is a Nox4 inhibitor. GLX481369 has antioxidant effects.