2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. NADPH Oxidase
  5. NADPH Oxidase Isoform

NADPH Oxidase

 

NADPH Oxidase Related Products (45):

Cat. No. Product Name Effect Purity
  • HY-100965
    Diphenyleneiodonium chloride
    		Inhibitor 99.91%
    Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.
  • HY-W010342
    6-Aminonicotinamide
    		99.95%
    6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (Ki=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells.
  • HY-N0088
    Apocynin
    		Inhibitor 99.94%
    Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model. Apocynin can also be used for cancer research. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass.
  • HY-123962
    G6PD activator AG1
    		99.54%
    G6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) agonist with an EC50 of 3 μM. G6PD is an oxidoreductase that catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone and the simultaneous reduction of NAD phosphate (NADP) to reduced NADP (NADPH). G6PD activator AG1 can reduce hemolysis of human erythrocytes.
  • HY-12804
    VAS2870
    		Inhibitor 98.79%
    VAS2870 is a NADPH oxidase (NOX) inhibitor.
  • HY-B0807A
    Prochlorperazine dimaleate
    		Inhibitor ≥98.0%
    Prochlorperazine dimaleate is a first-generation antipsychotic. Prochlorperazine dimaleate can be used in the research of chemotherapy-induced nausea and vomiting (CINV). Prochlorperazine dimaleate also possesses anticancer activity. Prochlorperazine dimaleate exhibits IC50 values of 6.4 μM, 4.5 μM and 2.3 μM for NOX1, NOX2 and NOX5, respectively.
  • HY-156425A
    NOX2-IN-2 diTFA
    		Inhibitor 98.15%
    NOX2-IN-2 diTFA (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. NOX2-IN-2 diTFA inhibits ROS production derived from NOX2 in cells.
  • HY-B0932R
    Levocarnitine propionate (hydrochloride) (Standard)
    		Inhibitor
    Adrenalone (hydrochloride) (Standard) is the analytical standard of Adrenalone (hydrochloride). This product is intended for research and analytical applications. Adrenalone hydrochloride is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Adrenalone hydrochloride is an inhibitor of dopamine β oxidase. Adrenalone hydrochloride is chemically similar to known norepinephrine transporter (NET) ligands with an IC50 of 36.9 μM.
  • HY-P5381
    gp91 ds-tat
    		Inhibitor 98.27%
    gp91 ds-tat is a biological active peptide. (NADPH oxidase assembly peptide inhibitor)
  • HY-101499A
    GKT136901 hydrochloride
    		Inhibitor 99.90%
    GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity.
  • HY-126213
    1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium
    		≥99.0%
    Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product generated following activation of the NADPH oxidase and lyso-PS signaling. Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium through the macrophage G2A functions to enhance existing receptor/ligand systems for resolution of neutrophilic inflammation.
  • HY-129997
    Luteolinidin chloride
    		Inhibitor 99.14%
    Luteolinidin chloride is a deoxyanthocyanidin isolated from the plant Sorghum bicolor with antioxidant activity. Luteolinidin chloride is a potent CD38 inhibitor (Ki=11.4 μM) and protects the heart from ischemia/reperfusion injury by preserving endothelial nitric oxide synthase (eNOS) function and preventing endothelial dysfunction. Luteolinidin chloride is also a competitive inhibitor of tyrosinase (IC50=3.7 μM) and blocks the production of melanin.
  • HY-119576
    Phox-I2
    		Inhibitor 99.52%
    Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production.
  • HY-Y1117
    Melamine
    		Activator 99.17%
    Melamine is an orally active inducer of Apoptosis. Melamine induces animal disease models. Melamine affects the activity of Sertoli cell and can be used for research on male reproductive function. Melamine also has neurotoxicity and nephrotoxicity. Melamine induces cognitive impairment and acute kidney injury models. Melamine can also be used to induce bladder cancer and urinary stone models.
  • HY-21509
    8-Hydroxycoumarin
    		99.63%
    8-Hydroxycoumarin is an intermediate in the microbial transformation of quinolone.
  • HY-N0449
    Nordihydrocapsaicin
    		Modulator 99.82%
    Nordihydrocapsaicin, an analog of Capsaicin (HY-10448), is an orally active compound with pungent properties and anti-cancer activities, which is found in fresh and processed peppers. Nordihydrocapsaicin can cause a burning sensation when consumed.
  • HY-153977
    GLX481304
    		Inhibitor 99.90%
    GLX481304 is a specific inhibitor of Nox-2 and -4, with IC50s of 1.25 μM. GLX481304 suppresses ROS production in isolated mouse cardiomyocytes and improves cardiomyocyte contractility. GLX481304 can be used for research of ischemic injury to the heart.
  • HY-P5328
    Noxa A BH3
    		99.61%
    Noxa A BH3 is a biological active peptide. (BH3 domain of Noxa protein)
  • HY-125938
    Cycloartenyl ferulate
    		98.98%
    Cycloartenyl ferulate (Cycloartenol ferulate) is one of the typical triterpene alcohols and possesses several biological activities including anti-oxidative activity, antiallergic activity, anti-inflammatory and anticancer activities.
  • HY-111447
    VAS 3947
    		Inhibitor 99.59%
    VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.