NADPH Oxidase

NADPH Oxidase Related Products (35):

By Effects:	Inhibitors (25) Activators (2) Modulator (1)

Cat. No.	Product Name	Effect	Purity

HY-100965

Diphenyleneiodonium chloride	Inhibitor	99.91%
Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC₅₀ of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.

HY-N0088

Apocynin	Inhibitor	99.94%
Apocynin is a selective NADPH-oxidase inhibitor with an IC₅₀ of 10 μM. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model. Apocynin can also be used for cancer research. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass.

HY-123962

G6PD activator AG1		99.54%
G6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) agonist with an EC50 of 3 μM. G6PD is an oxidoreductase that catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone and the simultaneous reduction of NAD phosphate (NADP) to reduced NADP (NADPH). G6PD activator AG1 can reduce hemolysis of human erythrocytes.

HY-12804

VAS2870	Inhibitor	98.45%
VAS2870 is a NADPH oxidase (NOX) inhibitor.

HY-101499A

GKT136901 hydrochloride	Inhibitor	99.90%
GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with K_is of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity.

HY-B0807A

Prochlorperazine dimaleate	Inhibitor	≥98.0%
Prochlorperazine dimaleate is a first-generation antipsychotic. Prochlorperazine dimaleate can be used in the research of chemotherapy-induced nausea and vomiting (CINV). Prochlorperazine dimaleate also possesses anticancer activity. Prochlorperazine dimaleate exhibits IC₅₀ values of 6.4 μM, 4.5 μM and 2.3 μM for NOX1, NOX2 and NOX5, respectively.

HY-W614507

Dihydronicotinamide riboside	Activator
Dihydronicotinamide riboside is a potent NAD⁺ concentration enhancer. Dihydronicotinamide riboside can be metabolized into NMNH by ATP-dependent kinase^{[1]< sup>.}

HY-170540

NOX4-IN-1	Inhibitor
NOX4-IN-1 (Compound 14m) is the inhibitor for NADPH oxidase 4 (NOX4), and blocks the generation of ROS. NOX4-IN-1 inhibits TGF-β1/Smad signaling pathway, decreases the expression of fibrosis-related proteins. NOX4-IN-1 inhibits the cell migration of NRK-49F.

HY-P5381

gp91 ds-tat	Inhibitor	98.27%
gp91 ds-tat is a biological active peptide. (NADPH oxidase assembly peptide inhibitor)

HY-129997

Luteolinidin chloride	Inhibitor	99.14%
Luteolinidin chloride is a deoxyanthocyanidin isolated from the plant Sorghum bicolor with antioxidant activity. Luteolinidin chloride is a potent CD38 inhibitor (K_i=11.4 μM) and protects the heart from ischemia/reperfusion injury by preserving endothelial nitric oxide synthase (eNOS) function and preventing endothelial dysfunction. Luteolinidin chloride is also a competitive inhibitor of tyrosinase (IC₅₀=3.7 μM) and blocks the production of melanin.

HY-126213

1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium		≥99.0%
Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product generated following activation of the NADPH oxidase and lyso-PS signaling. Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium through the macrophage G2A functions to enhance existing receptor/ligand systems for resolution of neutrophilic inflammation.

HY-119576

Phox-I2	Inhibitor	99.52%
Phox-I2 is a selective inhibitor of p67^phox-Rac1 interaction, binds to p67^phox with high affinity with a K_d of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production.

HY-Y1117

Melamine	Activator	99.17%
Melamine is an orally active inducer of Apoptosis. Melamine induces animal disease models. Melamine affects the activity of Sertoli cell and can be used for research on male reproductive function. Melamine also has neurotoxicity and nephrotoxicity. Melamine induces cognitive impairment and acute kidney injury models. Melamine can also be used to induce bladder cancer and urinary stone models.

HY-N0449

Nordihydrocapsaicin	Modulator	99.82%
Nordihydrocapsaicin, an analog of Capsaicin (HY-10448), is an orally active compound with pungent properties and anti-cancer activities, which is found in fresh and processed peppers. Nordihydrocapsaicin can cause a burning sensation when consumed.

HY-P5328

Noxa A BH3		99.61%
Noxa A BH3 is a biological active peptide. (BH3 domain of Noxa protein)

HY-153977

GLX481304	Inhibitor	99.90%
GLX481304 is a specific inhibitor of Nox-2 and -4, with IC₅₀s of 1.25 μM. GLX481304 suppresses ROS production in isolated mouse cardiomyocytes and improves cardiomyocyte contractility. GLX481304 can be used for research of ischemic injury to the heart.

HY-125938

Cycloartenyl ferulate		98.98%
Cycloartenyl ferulate (Cycloartenol ferulate) is one of the typical triterpene alcohols and possesses several biological activities including anti-oxidative activity, antiallergic activity, anti-inflammatory and anticancer activities.

HY-RS09461

NOX4 Human Pre-designed siRNA Set A	Inhibitor
NOX4 Human Pre-designed siRNA Set A contains three designed siRNAs for NOX4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-111447

VAS 3947	Inhibitor	99.59%
VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.

HY-W549903

p67phox-IN-1	Inhibitor
p67phox-IN-1 (Formula IIIa Compound) is an inhibitor targeting the interaction between Rac GTPase and p67^phox protein.

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