NADPH Oxidase Inhibitor

NADPH Oxidase Inhibitors (49):

Cat. No.	Product Name	Effect	Purity

HY-126195

Fluoflavine	Inhibitor	99.41%
Fluoflavine (ML-090) is a selective NOX1 inhibitor with an IC₅₀ of 90 nM. Fluoflavine has >100 selectivity for NOX1 over NOX2, NOX3, NOX4 (all IC₅₀>10 μM). ML-090 has an IC₅₀ of 360 nM in HEK293 cells.

HY-W549903

p67phox-IN-1	Inhibitor	98.64%
p67phox-IN-1 (Formula IIIa Compound) is an inhibitor targeting the interaction between Rac GTPase and p67^phox protein.

HY-105946

Hidrosmin	Inhibitor
Hidrosmin, a flavonoid, is derived from Diosmin (HY-N0178). hidrosmin exerts a beneficial effect against diabetic nephropathy (DN) by reducing inflammation, oxidative stress, and senescence pathways. Hidrosmin can be used for the research of venous insufficiency and diabetes mellitus.

HY-111447

VAS 3947	Inhibitor	99.59%
VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins.

HY-B0203B

(Rac)-Nebivolol	Inhibitor
(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity.

HY-RS09461

NOX4 Human Pre-designed siRNA Set A	Inhibitor
NOX4 Human Pre-designed siRNA Set A contains three designed siRNAs for NOX4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-160524

NOX2-IN-3	Inhibitor	98.08%
NOX2-IN-3 (compound 3) is an inhibitor of NOX2 (NADPH Oxidase 2). NOX2-IN-3 sensitizes tumor cells to MRTX1133 (HY-134813).

HY-156425A

NOX2-IN-2 diTFA	Inhibitor	98.15%
NOX2-IN-2 diTFA (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a K_i of 0.24 μM. NOX2-IN-2 diTFA inhibits ROS production derived from NOX2 in cells.

HY-B0932R

Levocarnitine propionate (hydrochloride) (Standard)	Inhibitor
Adrenalone (hydrochloride) (Standard) is the analytical standard of Adrenalone (hydrochloride). This product is intended for research and analytical applications. Adrenalone hydrochloride is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Adrenalone hydrochloride is an inhibitor of dopamine β oxidase. Adrenalone hydrochloride is chemically similar to known norepinephrine transporter (NET) ligands with an IC50 of 36.9 μM.

HY-P1435A

NoxA1ds TFA	Inhibitor
NoxA1ds TFA is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds TFA inhibits NOX1-derived O^2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds TFA can be used in the study of hypertension, atherosclerosis and tumors.

HY-157450

YF-Mo1	Inhibitor
YF-Mo1 (compound 9) is a CBR1 inhibitor with an IC₅₀ value of 1.1 μM.

HY-RS09457

NOX1 Human Pre-designed siRNA Set A	Inhibitor
NOX1 Human Pre-designed siRNA Set A contains three designed siRNAs for NOX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09462

Nox4 Mouse Pre-designed siRNA Set A	Inhibitor
Nox4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nox4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09459

Nox1 Rat Pre-designed siRNA Set A	Inhibitor
Nox1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nox1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-B0203BS2

(Rac)-Nebivolol-d₂,¹⁵N	Inhibitor
(Rac)-Nebivolol-d₂,¹⁵N is ¹⁵N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity.

HY-156425

NOX2-IN-2	Inhibitor
NOX2-IN-2 (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a K_i of 0.24 μM. NOX2-IN-2 inhibits ROS production derived from NOX2 in cells.

HY-170540

NOX4-IN-1	Inhibitor
NOX4-IN-1 (Compound 14m) is the inhibitor for NADPH oxidase 4 (NOX4), and blocks the generation of ROS. NOX4-IN-1 inhibits TGF-β1/Smad signaling pathway, decreases the expression of fibrosis-related proteins. NOX4-IN-1 inhibits the cell migration of NRK-49F.

HY-RS09458

Nox1 Mouse Pre-designed siRNA Set A	Inhibitor
Nox1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nox1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-B0530A

Azacyclonol hydrochloride	Inhibitor
Azacyclonol (γ-pipradol) hydrochloride is a compound with promising anticancer activity, showing effectiveness in inhibiting NOX-derived ROS in A549 human lung cancer cells. Azacyclonol hydrochloride exhibits enhanced proliferation inhibition against androgen-refractory cancer cell lines, specifically DU145 and PC-3. Azacyclonol hydrochloride demonstrates antitumor activity in DU145-xenografted chorioallantoic membrane tumor models. Azacyclonol hydrochloride also acts as a ligand for the M3 muscarinic acetylcholine receptor, which is overexpressed in ARPC. Azacyclonol hydrochloride effectively blocks carbachol-induced proliferation and NOX activity in DU145 cells. Azacyclonol hydrochloride can also be utilized for the treatment of chronic schizophrenia.

HY-P1908

sgp91 ds-tat Peptide 2, scrambled	Inhibitor
sgp91 ds-tat Peptide 2, scrambled is a scrambled sequence of NADPH oxidase inhibitor gp91 ds-tat peptide.

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