NOX2-IN-2 diTFA

Cat. No.: HY-156425A Purity: 98.15%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

NOX2-IN-2 diTFA (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a K_i of 0.24 μM. NOX2-IN-2 diTFA inhibits ROS production derived from NOX2 in cells.

For research use only. We do not sell to patients.

NOX2-IN-2 diTFA Chemical Structure

CAS No. : 2648709-80-0

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of NOX2-IN-2 diTFA:

NOX2-IN-2 Get quote

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NOX1 NOX2 NOX4

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

699.56

Formula

C₂₉H₂₇F₆N₇O₇

CAS No.

2648709-80-0

Appearance

Solid

Color

White to off-white

SMILES

NC1=NC2=CC=C(C=C2C=C1)OCC3=CN(N=N3)CCOCCOC4=CC=C5N=C(C=CC5=C4)N.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (178.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4295 mL	7.1473 mL	14.2947 mL
5 mM	0.2859 mL	1.4295 mL	2.8589 mL
10 mM	0.1429 mL	0.7147 mL	1.4295 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.15%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (247 KB) HNMR (297 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Jie Zang, et al.Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors. J Med Chem. 2023 Oct 19. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4295 mL	7.1473 mL	14.2947 mL	35.7367 mL
	5 mM	0.2859 mL	1.4295 mL	2.8589 mL	7.1473 mL
	10 mM	0.1429 mL	0.7147 mL	1.4295 mL	3.5737 mL
	15 mM	0.0953 mL	0.4765 mL	0.9530 mL	2.3824 mL
	20 mM	0.0715 mL	0.3574 mL	0.7147 mL	1.7868 mL
	25 mM	0.0572 mL	0.2859 mL	0.5718 mL	1.4295 mL
	30 mM	0.0476 mL	0.2382 mL	0.4765 mL	1.1912 mL
	40 mM	0.0357 mL	0.1787 mL	0.3574 mL	0.8934 mL
	50 mM	0.0286 mL	0.1429 mL	0.2859 mL	0.7147 mL
	60 mM	0.0238 mL	0.1191 mL	0.2382 mL	0.5956 mL
	80 mM	0.0179 mL	0.0893 mL	0.1787 mL	0.4467 mL
	100 mM	0.0143 mL	0.0715 mL	0.1429 mL	0.3574 mL

NOX2-IN-2 diTFA Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOX2-IN-2 diTFA2648709-80-0NADPH OxidaseNOXNOX2p47phox-p22phoxprotein-protein interactionROSInhibitorinhibitorinhibit

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