2. Signaling Pathways
  3. GPCR/G Protein
  4. Neuropeptide FF Receptor
  5. Neuropeptide FF Receptor Inhibitor

Neuropeptide FF Receptor Inhibitor

Neuropeptide FF Receptor Isoform Comparison

Neuropeptide FF Receptor Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-124680
    AC-263093 free base
    		Inhibitor 99.81%
    AC-263093 free base (AC-093) functionally activates NPFFR2 and blocks activation of NPFFR1 with pKis of 6.9 and 7.0, respectively. AC-263093 free base has the potential for reversing opiate tolerance research.
    .
  • HY-161405
    NPFF1-R antagonist 1
    		Inhibitor
    NPFF1-R antagonist 1 (compound 8b), a piperidine analogue, is a potent neuropeptide FF (NPFF) receptor antagonist. NPFF1-R antagonist 1 is 15-fold selective for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively.