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AC-263093 free base  (Synonyms: AC-093)

Cat. No.: HY-124680 Purity: 99.81%
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AC-263093 free base (AC-093) functionally activates NPFFR2 and blocks activation of NPFFR1 with pKis of 6.9 and 7.0, respectively. AC-263093 free base has the potential for reversing opiate tolerance research.
.

For research use only. We do not sell to patients.

AC-263093 free base Chemical Structure

AC-263093 free base Chemical Structure

CAS No. : 849459-86-5

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Based on 1 publication(s) in Google Scholar

AC-263093 free base Related Antibodies

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  • Purity & Documentation

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Description

AC-263093 free base (AC-093) functionally activates NPFFR2 and blocks activation of NPFFR1 with pKis of 6.9 and 7.0, respectively. AC-263093 free base has the potential for reversing opiate tolerance research[1].
.

Cellular Effect
Cell Line Type Value Description References
COS-1 EC50
2195 nM
Compound: AC-093
Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
[PMID: 22708927]
COS-1 EC50
527 nM
Compound: AC-093
Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
[PMID: 22708927]
In Vivo

AC-263093 free base (10 mg/kg; i.p.) totally reverses the tolerance to Morphine Sulfate in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats weighing 405±27 g[1]
Dosage: 10 mg/kg
Administration: IP; single dose
Result: Pre-treated decreased the Morphine (5 mg/kg; 7 days) analgesia scores.
Molecular Weight

319.98

Formula

C8H8Br2N4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

BrC1=CC=C(/C=N/NC(N)=N)C=C1Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (390.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1252 mL 15.6260 mL 31.2520 mL
5 mM 0.6250 mL 3.1252 mL 6.2504 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    AC-263093 was dissolved in 0.2 ml DMSO and brought up to 1.0 ml with saline.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1252 mL 15.6260 mL 31.2520 mL 78.1299 mL
5 mM 0.6250 mL 3.1252 mL 6.2504 mL 15.6260 mL
10 mM 0.3125 mL 1.5626 mL 3.1252 mL 7.8130 mL
15 mM 0.2083 mL 1.0417 mL 2.0835 mL 5.2087 mL
20 mM 0.1563 mL 0.7813 mL 1.5626 mL 3.9065 mL
25 mM 0.1250 mL 0.6250 mL 1.2501 mL 3.1252 mL
30 mM 0.1042 mL 0.5209 mL 1.0417 mL 2.6043 mL
40 mM 0.0781 mL 0.3906 mL 0.7813 mL 1.9532 mL
50 mM 0.0625 mL 0.3125 mL 0.6250 mL 1.5626 mL
60 mM 0.0521 mL 0.2604 mL 0.5209 mL 1.3022 mL
80 mM 0.0391 mL 0.1953 mL 0.3906 mL 0.9766 mL
100 mM 0.0313 mL 0.1563 mL 0.3125 mL 0.7813 mL
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AC-263093 free base Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AC-263093849459-86-5AC-093AC263093AC 263093AC093AC 093OthersNPFFR2NPFFR1Inhibitorinhibitorinhibit

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