2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Nuclear Hormone Receptor 4A/NR4A
  5. Nuclear Hormone Receptor 4A/NR4A Ligand

Nuclear Hormone Receptor 4A/NR4A Ligand

Nuclear Hormone Receptor 4A/NR4A Isoform Comparison

Nuclear Hormone Receptor 4A/NR4A Ligand (1):

Cat. No. Product Name Effect Purity
  • HY-P10873
    ST-CY14
    		Ligand
    ST-CY14 is an inhibitor for Nur77-PPARγ interaction with an EC50 of 3.15 μM, that binds to Nur77 (Kd=32 nM), blocks Nur77 from being ubiquitinated and degraded by PPARγ, reduces fatty acid uptake and mitochondrial respiration, and inhibits the transcription of CD36 and FABP4. ST-CY14 inhibits the proliferation and migration of cancer cell MCF7 and MDA-MB-231. ST-CY14 inhibits tumor growth and bone metastasis in mouse models.