1. Signaling Pathways
  2. Apoptosis
  3. Photosensitizer

Photosensitizer

Photosensitizers are light absorbers that alter the course of a photochemical reaction. They usually are catalysts. Photosensitizers have been used as light-responsive drugs with their imaging capabilities, easy synthesis, tunable energy levels, and biocompatibility, which make them an innovative tool for therapeutic approaches in treatment of various cancers. Among different methods for cancer therapy, photodynamic therapy (PDT) using a photosensitizer can take advantage of penetrated light into a targeted tissue for improving tumor control. The PDT comprises of three major components; photosensitizer, oxygen, and light source of appropriate wavelength, which when act together, generate a photochemical reaction. Depending on the part of the body being treated, the photosensitizing agent is either administered into the bloodstream through a vein or placed directly on the skin. By irradiation light on the targeted area, the excited photosensitizer emits energy in the form of heat and exhibits intersystem crossing (ISC), leading to the formation of reactive oxygen species (ROS) in triplet state.
Photosensitizers can function by many mechanisms, sometimes they donate an electron to the substrate, sometimes they abstract a hydrogen atom from the substrate. At the end of this process, the photosensitizer returns to its ground state, where it remains chemically intact, poised to absorb more light. One branch of chemistry which frequently utilizes photosensitizers is polymer chemistry, using photosensitizers in reactions such as photopolymerization, photocrosslinking, and photodegradation. Photosensitizers are also used to generate prolonged excited electronic states in organic molecules with uses in photocatalysis, photon upconversion and photodynamic therapy. Generally, photosensitizers absorb electromagnetic radiation consisting of infrared radiation, visible light radiation, and ultraviolet radiation and transfer absorbed energy into neighboring molecules[1][2].

Photosensitizer Related Products (40):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-162129
    Antitumor agent-131
    Antitumor agent-131 (Compound 2-p) is an ER fluorescent probe with an IC50 value of 23 nM for HepG2 tumor cells. Antitumor agent-131 can be used as a photosensitizer for the study of cancer photodynamics.
    Antitumor agent-131
  • HY-141861
    Anticancer agent 17
    Anticancer agent 17 displays potent anticancer activities against HeLa and A2780 cells with IC50 values of 0.19 μM and 0.09 μM, respectively.
    Anticancer agent 17
  • HY-128419
    Biguanidinium-porphyrin
    Biguanidinium-porphyrin is a mitochondria-targeting photosensitizer. Biguanidinium-porphyrin distributes within cell membranes with a large component in vesicles that correlated to some extent with the lysosomes and, upon longer exposures, in mitochondria and the cytosolic membrane.
    Biguanidinium-porphyrin
  • HY-146414
    Antitumor photosensitizer-1
    Antitumor photosensitizer-1 (Compound 8) is a potent photosensitizer. Antitumor photosensitizer-1 has outstanding photodynamic anti-tumor effects without obvious skin photo-toxicity, and can act as new agent candidates for photodynamic research.
    Antitumor photosensitizer-1
  • HY-125600
    LY219703
    LY219703 is a photoactivatable analogue of the antitumor diarylsulfonylurea sulofenur. LY219703 are distributed mainly in membranes, particularly those of organelles such as mitochondria.
    LY219703
  • HY-168854
    TBC-1
    TBC-1 is a chlorophyll-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT). TBC-1 efficiently generats Type-I ROS and endoplasmic reticulum targeting ability. TBC-1 shows biocompatibility and PDT efficiency in vitro under both normoxia and hypoxia.
    TBC-1
  • HY-161341
    β-Glucuronidase responsive conjugate 1
    β-Glucuronidase responsive conjugate 1 (compound 3) is a well-balanced photosensitizer which has photodynamic activity. β-Glucuronidase responsive conjugate 1 inhibits T-24 cell viability and growth with an IC50 of 0.2 μM. β-Glucuronidase responsive conjugate 1 can used to study bladder cancers.
    β-Glucuronidase responsive conjugate 1
  • HY-W738979
    Silicon naphthalocyanine dichloride
    Silicon naphthalocyanine dichloride is a photosensitizer with potential anti-tumor activity. Silicon naphthalocyanine dichloride is used as a cancer-inhibiting compound in photodynamic therapy. Silicon naphthalocyanine dichloride can effectively absorb light energy of a specific wavelength, thereby generating oxygen free radicals that help destroy cancer cells. The biocompatibility of Silicon naphthalocyanine dichloride makes it show good prospects in medical applications.
    Silicon naphthalocyanine dichloride
  • HY-170436
    NFh-NMe-2
    NFh-NMe-2 is a photosensitizer, that interacts with nitroreductase, generates singlet oxygen in tumor cells, exhibits cytotoxicity in cancer cells, and induces apoptosis. NFh-NMe-2 exhibits antitumor efficacy in mouse models.
    NFh-NMe-2
  • HY-133534
    PA-Nic TFA
    PA-Nic TFA is a photoactivatable nicotine, whcih can be photolyzed with ~405 nm laser flashes to efficiently release nicotine.
    PA-Nic TFA
  • HY-W504836
    Deuteroporphyrin IX dihydrochloride
    Deuteroporphyrin IX (dihydrochloride) is a photosensitizer with high lipophilicity and amphiphilicity, capable of providing photosensitivity for cell membrane systems. Deuteroporphyrin IX (dihydrochloride) can induce irreversible discharge elimination in individual neurons.
    Deuteroporphyrin IX dihydrochloride
  • HY-170883
    Type-I/-II Photosensitizer-1
    Type-I/-II Photosensitizer-1 (compound 8b) is a photosensitizer with anticancer activity. Type-I/-II Photosensitizer-1 exhibits significant phototoxicity against both A549 and 4T1 tumor cells. Type-I/-II Photosensitizer-1 shows a strong oxygen-independent antitumor effect under laser irradiation (IC50=1.50-1.76 μM).
    Type-I/-II Photosensitizer-1
  • HY-D2620
    CAR-2
    CAR-2 is a BODIPY-based photosensitizer that induces ferroptosis in photodynamic therapy (PDT) by targeting the endoplasmic reticulum (ER) and lipid droplets (LDs). CAR-2 exhibits phototoxicity in breast cancer cells with IC50 of 0.01-0.02 μM. CAR-2 exhibits antitumor efficacy in 4T1 xenograft mouse models.
    CAR-2
  • HY-W102471
    3-Acetylbenzophenone
    3-Acetylbenzophenone (Compound 2) is the photolysis product of Ketoprofen (HY-B0227). 3-Acetylbenzophenone promotes the photoperoxidation reaction of Linoleic acid (HY-N0729), exhibits free radical scavenging and photosensitizing activity.
    3-Acetylbenzophenone
  • HY-W011577
    Benzo[f]tetraphene
    Benzo[f]tetraphene (Dibenz[a,c]anthracene) is a polycyclic aromatic hydrocarbon with significant antitumor activity. Benzo[f]tetraphene is used as a luminescent probe in cell biology research and can effectively detect reactive oxygen species in biological systems. Benzo[f]tetraphene can also be used as a potential photosensitizer and shows good application prospects in photodynamic inhibition.
    Benzo[f]tetraphene
  • HY-W010713
    Meso-tetraphenylchlorin
    Meso-tetraphenylchlorin (TPCS2a) is a photosensitizer with poor water solubility, which limits its use in the blood circulation. However, TPCS2a@NPs nanoparticles can be prepared based on polylactic-co-polyethylene glycol acid (PLGA) polymer core loaded with TPCS2. Such nanoparticles can be coated with mesenchymal stem cell-derived plasma membranes (mMSCs) to form mMSC-TPCS2a@NPs, which prolongs blood circulation time and improves tumor targeting ability. Compared with uncoated TPCS2a@NPs, mMSC-TPCS2a@NPs can reduce macrophage uptake by 54% to 70% under different conditions. Both nanoparticle forms are effectively accumulated in MCF7 and MDA-MB-231 breast cancer cells, while uptake in normal breast epithelial cells MCF10A is significantly lower.
    Meso-tetraphenylchlorin
  • HY-W072496
    10-(3,5-Di-OMe-Ph)-9-mesityl-(1,3,6,8-tetra-OMe-acridinium) tetrafluoroborate
    10-(3,5-Di-OMe-Ph)-9-mesityl-(1,3,6,8-tetra-OMe-acridinium) tetrafluoroborate is a photocatalyst with the activity of enhancing the efficiency of organic reactions. 10-(3,5-Di-OMe-Ph)-9-mesityl-(1,3,6,8-tetra-OMe-acridinium) tetrafluoroborate is widely used in the synthesis of complex molecules and compounds. 10-(3,5-Di-OMe-Ph)-9-mesityl-(1,3,6,8-tetra-OMe-acridinium) tetrafluoroborate also exhibits excellent performance in photosensitization reactions.
    10-(3,5-Di-OMe-Ph)-9-mesityl-(1,3,6,8-tetra-OMe-acridinium) tetrafluoroborate
  • HY-Y0546R
    Benzophenone (Standard)
    Benzophenone (Standard) is the analytical standard of Benzophenone. This product is intended for research and analytical applications. Benzophenone standard is a photosensitizer, that absorbs UV light, transfers its energy to DNA, and triggers DNA damage. Benzophenone standard can be used as the fragrance enhancer, ultraviolet curing agent, additive in plastics, or the flavor ingredient. Benzophenone standard can also be used in the manufacturing of insecticides, agricultural chemicals, hypnotics, antihistamines, and other pharmaceuticals. Benzophenone standard exhibits certain carcinogenicity in mouse/rat models under long term exposure. Benzophenone standard exhibits estrogenic activity.
    Benzophenone (Standard)
  • HY-157503
    Photosensitizer-3
    Photosensitizer-3 is a photosensitizer that exhibits powerful selective killing effects on transfected HEK cells and affibody-targeted A431 cancer cells when exposed to near-infrared light excitation.
    Photosensitizer-3
  • HY-157051
    [Ru(DIP)2TAP]Cl2
    [Ru(DIP)2TAP]Cl2, Ruthenium(II) polypyridyl compound, is a photosensitizer. [Ru(DIP)2TAP]Cl2 can be used for the research of photodynamic therapy (PDT).
    [Ru(DIP)2TAP]Cl2