2. Signaling Pathways
  3. Apoptosis
  4. Transferrin Receptor
  5. Transferrin Receptor Inhibitor

Transferrin Receptor Inhibitor

Transferrin Receptor Inhibitors (6):

Cat. No. Product Name Effect Purity
  • HY-159569
    TfR-1-IN-1
    		Inhibitor
    TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC50 values ​​of 0.51, 0.46, and 0.48 μM, respectively.
  • HY-P991047
    Anti-CD71/TfR1 Antibody
    		Inhibitor ≥99.0%
    Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrin receptor (CD71; TfR) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001).
  • HY-P990856
    Anti-CD71 Antibody (OKT-9)
    		Inhibitor
    Anti-CD71 Antibody (OKT-9) is a kind of mouse IgG1κ chimeric antibody, targeting to human CD71. The recommend isotype control of Anti-CD71 Antibody (OKT-9): Mouse IgG1 kappa, Isotype Control (HY-P99977).
  • HY-P990129
    Anti-Mouse CD71/TfR1 Antibody (8D3)
    		Inhibitor
    Anti-Mouse CD71/TfR1 Antibody (8D3) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse CD71/TfR1.
  • HY-P990051
    Delpacibart
    		Inhibitor
    Delpacibart is a humanized IgG1κ antibody targeting TFRC. TFRC is the most important membrane protein that regulates intracellular iron transport processes.
  • HY-P99694
    Lepunafusp alfa
    		Inhibitor
    Lepunafusp alfa (JR-171) is a BBB-penetrable fusion protein consisting of J-Brain Cargo and IDUA (a lysosomal enzyme, α-L-iduronidase). Lepunafusp alfa can reduce concentration of heparan sulfate (HS) and dermatan sulfate (DS). Lepunafusp alfa can be used for research of mucopolysaccharidosis type I.