2. Signaling Pathways
  3. Apoptosis
  4. Transferrin Receptor
  5. Transferrin Receptor Inhibitor

Transferrin Receptor Inhibitor

Transferrin Receptor Inhibitor (1):

Cat. No. Product Name Effect Purity
  • HY-159569
    TfR-1-IN-1
    		Inhibitor
    TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC50 values ​​of 0.51, 0.46, and 0.48 μM, respectively.