2. Signaling Pathways
  3. Epigenetics
  4. WDR5

WDR5

WD repeat protein-5; WD40 repeat domain protein 5

WDR5 is a highly conserved WD40 repeat-containing protein that is essential for proper regulation of multiple cellular processes. WDR5 is best characterized as a core scaffolding component of histone methyltransferase complexes. WDR5 also plays a crucial role in mediating protein-protein interactions that sustain oncogenesis in human cancers. One prominent example is the interaction between the transcription factor MYC and WDR5, which is essential for oncogenic processes.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-168488
    WDR5 ligand 2
    		Ligand
    WDR5 ligand 2 is the ligand for WDR5 and can be used for synthesis of PROTAC WDR5 degrader 1 (HY-168487).
    WDR5 ligand 2
  • HY-157659
    WDR5-MLL1 antagonist 1
    		Antagonist
    WDR5-MLL1 antagonist 1 (compound 47) is a compound optimized through protein crystal structure guidance. It has stronger antagonistic activity against WDR5-MLL interaction with a dissociation constant (Kd) of 0.3μM.
    WDR5-MLL1 antagonist 1
  • HY-153728A
    (R)-WM-586
    		Inhibitor 99.07%
    (R)-WM-586 is the R-enantiomer of WM-586.
    (R)-WM-586
Cat. No. Product Name / Synonyms Application Reactivity