2. Signaling Pathways
  3. Epigenetics
  4. WDR5
  5. WDR5 Degrader

WDR5 Degrader

WDR5 Degraders (5):

Cat. No. Product Name Effect Purity
  • HY-141796
    MS67
    		Degrader 98.73%
    MS67 is a potent and selective WD40 repeat domain protein 5 (WDR5) degrader with a Kd of 63 nM. MS67 is inactive against other protein methyltransferases, kinases, GPCRs, ion channels, and transporters. MS67 shows potent acticancer effects.
  • HY-169389
    OICR41114
    		Degrader
    OICR41114 (PROTAC 4) is a WDR5-targeting PROTAC degrader. OICR41114 degrades endogenous WDR5 with an EC50 and Dmax values of 40 nM and 49%, respectively. OICR41114 degrades HiBiT-tagged WDR5 in a proteasome-dependent manner. OICR41114 is composed of target protein ligand (red part) Dimethyl-F-OICR-9429-COOH (HY-141799), E3 ligase ligand (blue part) OICR-8268-acrylic acid (HY-169390) and PROTAC linker (black part) Amino-PEG9-amine (HY-140210). The conjugate of E3 ligase ligand and linker is OICR-8268-acrylic acid-amino-PEG9-amine (HY-169391).
  • HY-162014
    WDR5 degrader-1
    		Degrader 98.00%
    WDR5 degrader-1 (compound 25) is a cereblon (CRBN)-recruiting WDR5 degrader. WDR5 degrader-1 selectively degraded WDR5 over the CRBN neo-substrate IKZF1.
  • HY-141797
    MS33
    		Degrader
    MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia.
  • HY-150403
    XF067-68
    		Degrader 99.56%
    XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5) (extracted from patent WO2019246570A1).
  • HY-RS15789
    WDR5B Human Pre-designed siRNA Set A
    		Degrader

    WDR5B Human Pre-designed siRNA Set A contains three designed siRNAs for WDR5B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-RS15785
    WDR5 Human Pre-designed siRNA Set A
    		Degrader

    WDR5 Human Pre-designed siRNA Set A contains three designed siRNAs for WDR5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
  • HY-150400
    XF056-132 free base
    		Degrader
    XF056-132 free base is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader.
  • HY-150400A
    XF056-132
    		Degrader
    XF056-132 is the salt form of trifluoroacetic acid (TFA, HY-21182).