Thonzonium bromide

Name: Thonzonium bromide
Brand: MedChemExpress
SKU: HY-B1246
Rating: 5.0 (5 reviews)

Cat. No.: HY-B1246 Purity: 99.86%: FAQs
Data Sheet SDS COA Handling Instructions

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Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC₅₀=69 μM).

For research use only. We do not sell to patients.

Thonzonium bromide Chemical Structure

CAS No. : 553-08-2

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 38	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Thonzonium bromide:

Thonzonium bromide (Standard) Get quote

5 Publications Citing Use of MCE Thonzonium bromide

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	11.2 μM Compound: Thonzonium Bromide	Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis	[PMID: 20966043]

In Vitro

Thonzonium bromide inhibits RANKL-induced OC formation, the appearance of OC-specific marker genes and bone-resorbing activity in vitro. Thonzonium bromide blocks the RANKL-induced activation of NF-κB, ERK and c-Fos as well as the induction of NFATc1 which is essential for OC formation. Thonzonium bromide disrupts F-actin ring formation resulting in disturbances in cytoskeletal structure in mature OCs during bone resorption. Thonzonium bromide exhibits protective effects in an in vivo murine model of LPS-induced calvarial osteolysis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

591.71

Formula

C₃₂H₅₅BrN₄O

CAS No.

553-08-2

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCC[N+](C)(CCN(CC1=CC=C(OC)C=C1)C2=NC=CC=N2)C.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (169.00 mM; Need ultrasonic)

DMSO : ≥ 30 mg/mL (50.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6900 mL	8.4501 mL	16.9002 mL
5 mM	0.3380 mL	1.6900 mL	3.3800 mL
10 mM	0.1690 mL	0.8450 mL	1.6900 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (269 KB) SDS (476 KB)

COA (240 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Zhu X, et al. Thonzonium bromide inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Biochem Pharmacol. 2016;104:118-130. [Content Brief]

[2]. Chan CY, et al. Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p). J Biol Chem. 2012;287(13):10236-10250. [Content Brief]

[3]. Sims KR, et al. Enhanced design and formulation of nanoparticles for anti-biofilm drug delivery. Nanoscale. 2018;11(1):219-236. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.6900 mL	8.4501 mL	16.9002 mL	42.2504 mL
	5 mM	0.3380 mL	1.6900 mL	3.3800 mL	8.4501 mL
	10 mM	0.1690 mL	0.8450 mL	1.6900 mL	4.2250 mL
	15 mM	0.1127 mL	0.5633 mL	1.1267 mL	2.8167 mL
	20 mM	0.0845 mL	0.4225 mL	0.8450 mL	2.1125 mL
	25 mM	0.0676 mL	0.3380 mL	0.6760 mL	1.6900 mL
	30 mM	0.0563 mL	0.2817 mL	0.5633 mL	1.4083 mL
	40 mM	0.0423 mL	0.2113 mL	0.4225 mL	1.0563 mL
	50 mM	0.0338 mL	0.1690 mL	0.3380 mL	0.8450 mL
H₂O	60 mM	0.0282 mL	0.1408 mL	0.2817 mL	0.7042 mL
	80 mM	0.0211 mL	0.1056 mL	0.2113 mL	0.5281 mL
	100 mM	0.0169 mL	0.0845 mL	0.1690 mL	0.4225 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.