2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. PF-06737007

PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.

For research use only. We do not sell to patients.

PF-06737007 Chemical Structure

PF-06737007 Chemical Structure

CAS No. : 1863905-38-7

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10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 114 In-stock
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10 mg USD 157 In-stock
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50 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

PF-06737007 Related Antibodies

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View All Trk Receptor Isoform Specific Products:

View All Isoforms
TrkA TrkB TrkC Trk

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Description

PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1].

IC50 & Target[1]

TrkA

7.7 nM (IC50, in cell-based assays)

TrkB

15 nM (IC50, in cell-based assays)

TrkC

3.9 nM (IC50, in cell-based assays)

In Vitro

PF-06737007 (Compound 13b) exhibits superb Trk selectivity with >95% inhibition of TrkA with no other kinase being inhibited by >40% at 1 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-06737007 Related Antibodies
Molecular Weight

528.49

Formula

C25H28F4N2O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N)C1=CC=C(OCC(C)(O)C)C=C1O[C@@H]2[C@H](F)CN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (189.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8922 mL 9.4609 mL 18.9218 mL
5 mM 0.3784 mL 1.8922 mL 3.7844 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8922 mL 9.4609 mL 18.9218 mL 47.3046 mL
5 mM 0.3784 mL 1.8922 mL 3.7844 mL 9.4609 mL
10 mM 0.1892 mL 0.9461 mL 1.8922 mL 4.7305 mL
15 mM 0.1261 mL 0.6307 mL 1.2615 mL 3.1536 mL
20 mM 0.0946 mL 0.4730 mL 0.9461 mL 2.3652 mL
25 mM 0.0757 mL 0.3784 mL 0.7569 mL 1.8922 mL
30 mM 0.0631 mL 0.3154 mL 0.6307 mL 1.5768 mL
40 mM 0.0473 mL 0.2365 mL 0.4730 mL 1.1826 mL
50 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.9461 mL
60 mM 0.0315 mL 0.1577 mL 0.3154 mL 0.7884 mL
80 mM 0.0237 mL 0.1183 mL 0.2365 mL 0.5913 mL
100 mM 0.0189 mL 0.0946 mL 0.1892 mL 0.4730 mL
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PF-06737007 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-067370071863905-38-7PF06737007PF 06737007Trk ReceptorTropomyosin related kinase receptorInhibitorinhibitorinhibit

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