YM-58790

Cat. No.: HY-101679 Purity: 98.21%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

YM-58790 is a potent antagonist of mAChR. YM-58790 binds M1, M2, M3 with K_i values of 28 nM, 260 nM, and 15 nM. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction in rats.

For research use only. We do not sell to patients.

YM-58790 Chemical Structure

CAS No. : 214558-72-2

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 390	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1250	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2020	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3250	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Other Forms of YM-58790:

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•Related Screening Libraries:

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View All mAChR Isoform Specific Products:

View All Isoforms

mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

mAChR3

15 nM (Ki)

mAChR1

28 nM (Ki)

mAChR2

260 nM (Ki)

In Vitro

YM-58790 (compound 18b) (0-1 μM) shows potent inhibitory effect on urinary bladder contraction, but has little effect on bradycardia. YM-58790 exhibits selective antagonism between urinary bladder contraction and salivary secretion in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

YM-58790 (3 mg/kg, i.v.) has no effect on oxotremorine-induced tremor in mice^[1].
YM-58790 (6.0 mg/kg; i.v.) shows poor M1 and M2 antagonism effect in vivo on McN-A343-induced pressor in pithed rats, but displays potent efficacy on M3 antagonism with an ED₃₀ value of 0.36 mg/kg (i.v.) and an ID₅₀ value of 2.4 mg/kg (i.v.)^[1].
YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction, similar to Oxybutynin (HY-B0267), and has about ten times less inhibitory effect on oxotremorine-induced salivary secretion than oxybutynin in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

466.01

Formula

C₂₇H₃₂ClN₃O₂

CAS No.

214558-72-2

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(OC1CCN(CC2=CC=C(NC)C=C2)CC1)NC(C3=CC=CC=C3)C4=CC=CC=C4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (214.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1459 mL	10.7294 mL	21.4588 mL
5 mM	0.4292 mL	2.1459 mL	4.2918 mL
10 mM	0.2146 mL	1.0729 mL	2.1459 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.21%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (246 KB) HNMR (189 KB) RP-HPLC (170 KB) LCMS (416 KB)

Handling Instructions (2659 KB)

References

[1]. Naito R, et al. Selective muscarinic antagonists. I. Synthesis and antimuscarinic properties of 4-piperidyl benzhydrylcarbamate derivatives. Chem Pharm Bull (Tokyo). 1998 Aug;46(8):1274-85. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1459 mL	10.7294 mL	21.4588 mL	53.6469 mL
	5 mM	0.4292 mL	2.1459 mL	4.2918 mL	10.7294 mL
	10 mM	0.2146 mL	1.0729 mL	2.1459 mL	5.3647 mL
	15 mM	0.1431 mL	0.7153 mL	1.4306 mL	3.5765 mL
	20 mM	0.1073 mL	0.5365 mL	1.0729 mL	2.6823 mL
	25 mM	0.0858 mL	0.4292 mL	0.8584 mL	2.1459 mL
	30 mM	0.0715 mL	0.3576 mL	0.7153 mL	1.7882 mL
	40 mM	0.0536 mL	0.2682 mL	0.5365 mL	1.3412 mL
	50 mM	0.0429 mL	0.2146 mL	0.4292 mL	1.0729 mL
	60 mM	0.0358 mL	0.1788 mL	0.3576 mL	0.8941 mL
	80 mM	0.0268 mL	0.1341 mL	0.2682 mL	0.6706 mL
	100 mM	0.0215 mL	0.1073 mL	0.2146 mL	0.5365 mL

YM-58790 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM-58790214558-72-2YM58790YM 58790mAChRMuscarinic acetylcholine receptorbladder pressuerrhythmic contractionreflexly-evoked rhythmic contractionInhibitorinhibitorinhibit

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