(+)-Viroallosecurinine

Cat. No.: HY-N5002 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

(+)-Viroallosecurinine, a cytotoxic alkaloid, exhibits a MIC of 0.48 μg/mL for Ps. Aeruginosa and Staph. aureus. Antibacterial activity.

For research use only. We do not sell to patients.

(+)-Viroallosecurinine Chemical Structure

CAS No. : 1857-30-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (+)-Viroallosecurinine:

Allosecurinine Get quote

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

(+)-Viroallosecurinine, a cytotoxic alkaloid, exhibits a MIC of 0.48 μg/mL for Ps. Aeruginosa and Staph. aureus^[1]. Antibacterial activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	6.1 μM Compound: 1	Antiproliferative activity against human A375 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay Antiproliferative activity against human A375 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay	[PMID: 27096049]
A-375	IC₅₀	6.1 μM Compound: 1	Cytotoxicity against human A375 cells assessed as growth inhibition after 72 hrs by ATPlite assay Cytotoxicity against human A375 cells assessed as growth inhibition after 72 hrs by ATPlite assay	[PMID: 26793989]
A549	IC₅₀	> 10 μM Compound: 1	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay	[PMID: 27096049]
A549	IC₅₀	> 10 μM Compound: 1	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by ATPlite assay Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by ATPlite assay	[PMID: 26793989]
A549	IC₅₀	> 10 μM Compound: 12	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 31082231]
A549	IC₅₀	23.59 μM Compound: Securinine	Growth inhibition of human A549 cells after 72 hrs by MTT assay Growth inhibition of human A549 cells after 72 hrs by MTT assay	[PMID: 27344492]
A549	IC₅₀	25 μM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by Coulter counter analysis Cytotoxicity against human A549 cells after 72 hrs by Coulter counter analysis	[PMID: 26793989]
BV-2	IC₅₀	1.1 μM Compound: 12	Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitrite production after 24 hrs by Griess assay Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitrite production after 24 hrs by Griess assay	[PMID: 31082231]
HCT-116	IC₅₀	> 10 μM Compound: 1	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay	[PMID: 27096049]
HCT-116	IC₅₀	> 10 μM Compound: 1	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by ATPlite assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by ATPlite assay	[PMID: 26793989]
HCT-15	IC₅₀	> 10 μM Compound: 12	Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay	[PMID: 31082231]
HeLa	IC₅₀	50.23 μM Compound: Securinine	Growth inhibition of human HeLa cells after 72 hrs by MTT assay Growth inhibition of human HeLa cells after 72 hrs by MTT assay	[PMID: 27344492]
HepG2	IC₅₀	36.87 μM Compound: Securinine	Growth inhibition of human HepG2 cells after 72 hrs by MTT assay Growth inhibition of human HepG2 cells after 72 hrs by MTT assay	[PMID: 27344492]
HL-60	IC₅₀	> 10 μM Compound: 1	Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay	[PMID: 27096049]
HL-60	IC₅₀	> 10 μM Compound: 1	Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by ATPlite assay Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by ATPlite assay	[PMID: 26793989]
MCF7	IC₅₀	25 μM Compound: 1	Antiproliferative activity against human MCF7 cells by CCK8 assay Antiproliferative activity against human MCF7 cells by CCK8 assay	[PMID: 27096049]
MCF7	IC₅₀	25 μM Compound: 1	Cytotoxicity against human MCF7 cells assessed as growth inhibition by CCK8 assay Cytotoxicity against human MCF7 cells assessed as growth inhibition by CCK8 assay	[PMID: 26793989]
SH-SY5Y	IC₅₀	78.9 μM Compound: Securinine	Growth inhibition of human SH-SY5Y cells after 72 hrs by MTT assay Growth inhibition of human SH-SY5Y cells after 72 hrs by MTT assay	[PMID: 27344492]
SK-MEL-2	IC₅₀	> 10 μM Compound: 12	Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay	[PMID: 31082231]
SK-OV-3	IC₅₀	> 10 μM Compound: 12	Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay	[PMID: 31082231]
SW480	IC₅₀	25.855 μM Compound: Securinine	Antiproliferative activity against human SW480 cells after 48 hrs by MTT assay Antiproliferative activity against human SW480 cells after 48 hrs by MTT assay	[PMID: 27344492]

Molecular Weight

217.26

Formula

C₁₃H₁₅NO₂

CAS No.

1857-30-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O1)C=C2[C@]13[C@](CCCC4)([H])N4[C@H](C3)C=C2

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 22.5 mg/mL (103.56 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6028 mL	23.0139 mL	46.0278 mL
5 mM	0.9206 mL	4.6028 mL	9.2056 mL
10 mM	0.4603 mL	2.3014 mL	4.6028 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (262 KB) HNMR (298 KB) RP-HPLC (112 KB)

Handling Instructions (2659 KB)

References

[1]. Mensah JL, et al. Antibacterial activity of the leaves of Phyllanthus discoideus. J Ethnopharmacol. 1990 Feb;28(1):129-33. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.6028 mL	23.0139 mL	46.0278 mL	115.0695 mL
	5 mM	0.9206 mL	4.6028 mL	9.2056 mL	23.0139 mL
	10 mM	0.4603 mL	2.3014 mL	4.6028 mL	11.5070 mL
	15 mM	0.3069 mL	1.5343 mL	3.0685 mL	7.6713 mL
	20 mM	0.2301 mL	1.1507 mL	2.3014 mL	5.7535 mL
	25 mM	0.1841 mL	0.9206 mL	1.8411 mL	4.6028 mL
	30 mM	0.1534 mL	0.7671 mL	1.5343 mL	3.8357 mL
	40 mM	0.1151 mL	0.5753 mL	1.1507 mL	2.8767 mL
	50 mM	0.0921 mL	0.4603 mL	0.9206 mL	2.3014 mL
	60 mM	0.0767 mL	0.3836 mL	0.7671 mL	1.9178 mL
	80 mM	0.0575 mL	0.2877 mL	0.5753 mL	1.4384 mL
	100 mM	0.0460 mL	0.2301 mL	0.4603 mL	1.1507 mL