A-77636 hydrochloride

Name: A-77636 hydrochloride
Brand: MedChemExpress
SKU: HY-103416
Rating: 4.5 (1 reviews)

Cat. No.: HY-103416 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pK_i=7.40; K_i=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor.

For research use only. We do not sell to patients.

A-77636 hydrochloride Chemical Structure

CAS No. : 145307-34-2

Size	Price	Stock	Quantity
5 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of A-77636 hydrochloride:

A-77636 Get quote

1 Publications Citing Use of MCE A-77636 hydrochloride

•Nature. 2023 Dec;624(7992):672-681. [Abstract]

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

A-77636 (0.1-1 mg/kg) exerts a suppressant effect on food intake, due principally to a reduction in meal size and duration^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male hooded rat^[1]
Dosage:	0.1, 0.3 and 1.0 mg/kg
Administration:	S.c.
Result:	Exerted a suppressant effect on food intake, due principally to a reduction in meal size and duration.

Molecular Weight

365.89

Formula

C₂₀H₂₈ClNO₃

CAS No.

145307-34-2

Appearance

Solid

Color

Brown to black

SMILES

[H]Cl.NC[C@@H]1O[C@@H](CC2=C(O)C(O)=CC=C12)C34C[C@H](C5)C[C@H](C[C@H]5C4)C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 33 mg/mL (90.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7331 mL	13.6653 mL	27.3306 mL
5 mM	0.5466 mL	2.7331 mL	5.4661 mL
10 mM	0.2733 mL	1.3665 mL	2.7331 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (253 KB) Elemental Analysis Report (111 KB)

Handling Instructions (2659 KB)

References

[1]. Kebabian JW, et al. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur J Pharmacol. 1992;229(2-3):203-209. [Content Brief]

[2]. Smith LA, et al. The actions of a D-1 agonist in MPTP treated primates show dependence on both D-1 and D-2 receptor function and tolerance on repeated administration. J Neural Transm (Vienna). 2002;109(2):123-140. [Content Brief]

[3]. Cooper SJ, et al. The anorectic effect of the selective dopamine D1-receptor agonist A-77636 determined by meal pattern analysis in free-feeding rats. Eur J Pharmacol. 2006;532(3):253-257. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7331 mL	13.6653 mL	27.3306 mL	68.3265 mL
	5 mM	0.5466 mL	2.7331 mL	5.4661 mL	13.6653 mL
	10 mM	0.2733 mL	1.3665 mL	2.7331 mL	6.8327 mL
	15 mM	0.1822 mL	0.9110 mL	1.8220 mL	4.5551 mL
	20 mM	0.1367 mL	0.6833 mL	1.3665 mL	3.4163 mL
	25 mM	0.1093 mL	0.5466 mL	1.0932 mL	2.7331 mL
	30 mM	0.0911 mL	0.4555 mL	0.9110 mL	2.2776 mL
	40 mM	0.0683 mL	0.3416 mL	0.6833 mL	1.7082 mL
	50 mM	0.0547 mL	0.2733 mL	0.5466 mL	1.3665 mL
	60 mM	0.0456 mL	0.2278 mL	0.4555 mL	1.1388 mL
	80 mM	0.0342 mL	0.1708 mL	0.3416 mL	0.8541 mL