2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. AAT-008

AAT-008 is a potent, selective, and orally active prostaglandin EP4 receptor antagonist with Kis of 0.97 and 6.1 nM for recombinant human EP4 and recombinant rat EP4, respectively.

For research use only. We do not sell to patients.

AAT-008 Chemical Structure

AAT-008 Chemical Structure

CAS No. : 847727-81-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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 USD 132 In-stock
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10 mM * 1 mL in DMSO USD 132 In-stock
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5 mg USD 120 In-stock
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25 mg USD 450 In-stock
50 mg USD 720 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

AAT-008 Related Antibodies

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Description

AAT-008 is a potent, selective, and orally active prostaglandin EP4 receptor antagonist with Kis of 0.97 and 6.1 nM for recombinant human EP4 and recombinant rat EP4, respectively[1].

IC50 & Target[1]

EP4

0.97 nM (Ki)

EP4

6.1 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
16.3 nM
Compound: 4j; AAT-008
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP level by HTS assay
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP level by HTS assay
[PMID: 28169162]
Molecular Weight

414.81

Formula

C21H16ClFN2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C([C@@H](NC(C2=CC(Cl)=CN=C2OC3=CC=CC(F)=C3)=O)C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (241.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4107 mL 12.0537 mL 24.1074 mL
5 mM 0.4821 mL 2.4107 mL 4.8215 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4107 mL 12.0537 mL 24.1074 mL 60.2686 mL
5 mM 0.4821 mL 2.4107 mL 4.8215 mL 12.0537 mL
10 mM 0.2411 mL 1.2054 mL 2.4107 mL 6.0269 mL
15 mM 0.1607 mL 0.8036 mL 1.6072 mL 4.0179 mL
20 mM 0.1205 mL 0.6027 mL 1.2054 mL 3.0134 mL
25 mM 0.0964 mL 0.4821 mL 0.9643 mL 2.4107 mL
30 mM 0.0804 mL 0.4018 mL 0.8036 mL 2.0090 mL
40 mM 0.0603 mL 0.3013 mL 0.6027 mL 1.5067 mL
50 mM 0.0482 mL 0.2411 mL 0.4821 mL 1.2054 mL
60 mM 0.0402 mL 0.2009 mL 0.4018 mL 1.0045 mL
80 mM 0.0301 mL 0.1507 mL 0.3013 mL 0.7534 mL
100 mM 0.0241 mL 0.1205 mL 0.2411 mL 0.6027 mL
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AAT-008 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AAT-008847727-81-5AAT008AAT 008Prostaglandin ReceptororalprostaglandinEP4 receptorinflammationInhibitorinhibitorinhibit

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