2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. ABBV-467

ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM). ABBV-467 induces apoptosis. ABBV-467 induces cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma.

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ABBV-467 Chemical Structure

ABBV-467 Chemical Structure

CAS No. : 2287186-66-5

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1 mg USD 190 In-stock
5 mg USD 480 In-stock
10 mg USD 780 In-stock
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Based on 1 publication(s) in Google Scholar

ABBV-467 Related Antibodies

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View All Bcl-2 Family Isoform Specific Products:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Description

ABBV-467 is a selective MCL-1 inhibitor (Ki: <0.01 nM). ABBV-467 induces apoptosis. ABBV-467 induces cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma[1].

IC50 & Target

MCL-1[1].
In Vitro

ABBV-467 (1 nM - 10 μM, 24 h) inhibits BAK protein expression in BAK-deficient SKBR3 cells[1].
ABBV-467 (0.01–10 nM, 24 hours) induces apoptosis in AMO-1 cell line[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ABBV-467 Related Antibodies

Western Blot Analysis[1]

Cell Line: BAK-deficient SKBR3 cells (breast cancer)
Concentration: 1 nM to 10 μM
Incubation Time: 24 h
Result: Induced dose-dependent apoptosis after treatment.

Cell Viability Assay[1]

Cell Line: AMO-1 cell line (multiple myeloma)
Concentration: 1 nM to 10 μM
Incubation Time: 24 h
Result: Resulted in a significant reduction in BAK protein expression.
In Vivo

ABBV-467 (12.5 mg/kg, i.v., once per week for 3 weeks) exhibits significant antitumor activity in t(4;14)-translocated multiple myeloma mouse models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: t(4;14) (chromosomal translocation between chromosome 4 and chromosome 14)-translocated high-risk multiple myeloma NOD-SCID mice[1]
Dosage: 6.25 mg/kg and 12.5 mg/kg
Administration: Intravenous injection (i.v.), once per week for 3 weeks
Result: Resulted in a maximal tumor delay of 82% at 6.25 mg/kg and complete tumor regression at 12.5 mg/kg.
Molecular Weight

1037.98

Formula

C53H51Cl2FN6O9S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(O)[C@@H](CC1=CC2=CC=C1OCC3=NC(C4=CC=C(OC[C@H]5OCCOC5)C=C4)=NC=C3)OC6=NC=NC7=C6C(C8=C(C)C(Cl)=C(O[C@@H](CO2)CN9CCN(C)CC9)C(Cl)=C8C)=C(C%10=CC=C(F)C=C%10)S7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (120.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9634 mL 4.8170 mL 9.6341 mL
5 mM 0.1927 mL 0.9634 mL 1.9268 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.78%

SDS (252 KB)

COA (259 KB) HNMR (310 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9634 mL 4.8170 mL 9.6341 mL 24.0852 mL
5 mM 0.1927 mL 0.9634 mL 1.9268 mL 4.8170 mL
10 mM 0.0963 mL 0.4817 mL 0.9634 mL 2.4085 mL
15 mM 0.0642 mL 0.3211 mL 0.6423 mL 1.6057 mL
20 mM 0.0482 mL 0.2409 mL 0.4817 mL 1.2043 mL
25 mM 0.0385 mL 0.1927 mL 0.3854 mL 0.9634 mL
30 mM 0.0321 mL 0.1606 mL 0.3211 mL 0.8028 mL
40 mM 0.0241 mL 0.1204 mL 0.2409 mL 0.6021 mL
50 mM 0.0193 mL 0.0963 mL 0.1927 mL 0.4817 mL
60 mM 0.0161 mL 0.0803 mL 0.1606 mL 0.4014 mL
80 mM 0.0120 mL 0.0602 mL 0.1204 mL 0.3011 mL
100 mM 0.0096 mL 0.0482 mL 0.0963 mL 0.2409 mL
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ABBV-467 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABBV-4672287186-66-5ABBV467ABBV 467Bcl-2 FamilyApoptosisAMO-1 xenograftOPM-2 xenograftcancermultiple myelomatumorInhibitorinhibitorinhibit

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