2. Cell Cycle/DNA Damage
  3. CDK
  4. Abemaciclib metabolite M20-d8

Abemaciclib metabolite M20-d8  (Synonyms: LSN3106726-d8)

Cat. No.: HY-129336S Purity: 97.01%
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Abemaciclib metabolite M20-d8 is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor[1].

For research use only. We do not sell to patients.

Abemaciclib metabolite M20-d<sub>8</sub> Chemical Structure

Abemaciclib metabolite M20-d8 Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of Abemaciclib metabolite M20-d8:

Abemaciclib metabolite M20-d8 Related Antibodies

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Description

Abemaciclib metabolite M20-d8 is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor[1].

IC50 & Target[1]

CDK4

 

CDK6

 

Molecular Weight

530.64

Formula

C27H24D8F2N8O
Unlabeled CAS

2138499-06-4
Appearance

Solid

Color

White to yellow

SMILES

CC(C)N1C2=CC(C3=C(C=NC(NC4=NC=C(C=C4)CN(C([2H])(C5([2H])[2H])[2H])C([2H])(C([2H])(N5CC)[2H])[2H])=N3)F)=CC(F)=C2N=C1CO
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (9.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 5 mg/mL (9.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8845 mL 9.4226 mL 18.8452 mL
5 mM 0.3769 mL 1.8845 mL 3.7690 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 1.8845 mL 9.4226 mL 18.8452 mL 47.1129 mL
5 mM 0.3769 mL 1.8845 mL 3.7690 mL 9.4226 mL
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Abemaciclib metabolite M20-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abemaciclib metabolite M20-d8LSN3106726-d8CDKCyclin dependent kinasemetabolitemantle cell lymphomadeuteriumInhibitorinhibitorinhibit

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