2. Cell Cycle/DNA Damage
  3. CDK
  4. Abemaciclib metabolite M20

Abemaciclib metabolite M20  (Synonyms: LSN3106726)

Cat. No.: HY-129336 Purity: 96.02%
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Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor for the treatment of cancer.

For research use only. We do not sell to patients.

Abemaciclib metabolite M20 Chemical Structure

Abemaciclib metabolite M20 Chemical Structure

CAS No. : 2138499-06-4

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Based on 4 publication(s) in Google Scholar

Other Forms of Abemaciclib metabolite M20:

Abemaciclib metabolite M20 Related Antibodies

Top Publications Citing Use of Products

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Description

Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor for the treatment of cancer[1].

IC50 & Target[1]

CDK4

 

CDK6

 

In Vitro

Abemaciclib metabolite M20 (200 nM and 500 nM, 6-8 days) induces senescence in breast cancer cells[2].
Abemaciclib metabolite M20 inhibits the growth and cell cycle progression of non-small cell lung cancer (NSCLC) cells, colorectal cancer (CRC) cells, and breast cancer cells in a concentration-dependent manner[2].
Abemaciclib metabolite has an IC50 value for CDK4 and CDK6 in the range of 1-3 nM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Abemaciclib metabolite M20 Related Antibodies
Molecular Weight

522.59

Formula

C27H32F2N8O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OCC1=NC2=C(F)C=C(C3=NC(NC4=NC=C(CN5CCN(CC)CC5)C=C4)=NC=C3F)C=C2N1C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (9.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9135 mL 9.5677 mL 19.1355 mL
5 mM 0.3827 mL 1.9135 mL 3.8271 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9135 mL 9.5677 mL 19.1355 mL 47.8386 mL
5 mM 0.3827 mL 1.9135 mL 3.8271 mL 9.5677 mL
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Abemaciclib metabolite M20 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abemaciclib metabolite M202138499-06-4LSN3106726Abemaciclib metabolite M 20Abemaciclib metabolite M-20LSN 3106726LSN-3106726CDKCyclin dependent kinaseactive metaboliteanti-cancernon-small cell lung cancer cellsNSCLCcolorectal cancer cellsbreast cancer cellsInhibitorinhibitorinhibit

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