2. PROTAC
  3. Ligands for Target Protein for PROTAC
  4. ABM-14

ABM-14 is a ligand for targeting androgen receptor (AR) for PROTAC. ABM-14 binds to a ligand for VHL via linker to form ARCC-4 (HY-130492) to degrade AR.

For research use only. We do not sell to patients.

ABM-14 Chemical Structure

ABM-14 Chemical Structure

CAS No. : 1973408-76-2

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5 mg USD 220 In-stock
10 mg USD 350 In-stock
25 mg USD 700 In-stock
50 mg USD 1100 In-stock
100 mg USD 1780 In-stock
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Based on 1 publication(s) in Google Scholar

ABM-14 Related Antibodies

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Description

ABM-14 is a ligand for targeting androgen receptor (AR) for PROTAC. ABM-14 binds to a ligand for VHL via linker to form ARCC-4 (HY-130492) to degrade AR[1].

Molecular Weight

481.49

Formula

C25H18F3N3O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=CC=C(N(C(N(C2=CC=C(C3=CC=C(O)C=C3)C=C2)C4(C)C)=S)C4=O)C=C1C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (103.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0769 mL 10.3844 mL 20.7689 mL
5 mM 0.4154 mL 2.0769 mL 4.1538 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.17%

SDS (251 KB)

COA (249 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0769 mL 10.3844 mL 20.7689 mL 51.9222 mL
5 mM 0.4154 mL 2.0769 mL 4.1538 mL 10.3844 mL
10 mM 0.2077 mL 1.0384 mL 2.0769 mL 5.1922 mL
15 mM 0.1385 mL 0.6923 mL 1.3846 mL 3.4615 mL
20 mM 0.1038 mL 0.5192 mL 1.0384 mL 2.5961 mL
25 mM 0.0831 mL 0.4154 mL 0.8308 mL 2.0769 mL
30 mM 0.0692 mL 0.3461 mL 0.6923 mL 1.7307 mL
40 mM 0.0519 mL 0.2596 mL 0.5192 mL 1.2981 mL
50 mM 0.0415 mL 0.2077 mL 0.4154 mL 1.0384 mL
60 mM 0.0346 mL 0.1731 mL 0.3461 mL 0.8654 mL
80 mM 0.0260 mL 0.1298 mL 0.2596 mL 0.6490 mL
100 mM 0.0208 mL 0.1038 mL 0.2077 mL 0.5192 mL
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ABM-14 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABM-141973408-76-2ABM14ABM 14Ligands for Target Protein for PROTACTarget Protein-binding MoietyARCC-4androgenreceptorARInhibitorinhibitorinhibit

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HY-131388
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