2. GPCR/G Protein Neuronal Signaling
  3. MCHR1 (GPR24)
  4. Ac-hMCH(6-16)-NH2

Ac-hMCH(6-16)-NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC50 values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R.

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Ac-hMCH(6-16)-NH2 Chemical Structure

Ac-hMCH(6-16)-NH2 Chemical Structure

CAS No. : 353486-32-5

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Based on 1 publication(s) in Google Scholar

Ac-hMCH(6-16)-NH2 Related Antibodies

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Description

Ac-hMCH(6-16)-NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC50 values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R[1].

In Vitro

Ac-hMCH(6-16)-NH2 exhibits EC50 values of 20 nM and 98 nM for MCH-1R and MCH-2R in aequorin functional assay, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ac-hMCH(6-16)-NH2 Related Antibodies
Molecular Weight

1392.72

Formula

C58H97N21O13S3
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-NH2 (disulfide bridge:Cys2-Cys11)
Sequence Shortening

Ac-RCMLGRVYRPC-NH2 (disulfide bridge:Cys2-Cys11)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (71.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7180 mL 3.5901 mL 7.1802 mL
5 mM 0.1436 mL 0.7180 mL 1.4360 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7180 mL 3.5901 mL 7.1802 mL 17.9505 mL
5 mM 0.1436 mL 0.7180 mL 1.4360 mL 3.5901 mL
10 mM 0.0718 mL 0.3590 mL 0.7180 mL 1.7950 mL
15 mM 0.0479 mL 0.2393 mL 0.4787 mL 1.1967 mL
20 mM 0.0359 mL 0.1795 mL 0.3590 mL 0.8975 mL
25 mM 0.0287 mL 0.1436 mL 0.2872 mL 0.7180 mL
30 mM 0.0239 mL 0.1197 mL 0.2393 mL 0.5983 mL
40 mM 0.0180 mL 0.0898 mL 0.1795 mL 0.4488 mL
50 mM 0.0144 mL 0.0718 mL 0.1436 mL 0.3590 mL
60 mM 0.0120 mL 0.0598 mL 0.1197 mL 0.2992 mL
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Ac-hMCH(6-16)-NH2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-hMCH(6-16)-NH2353486-32-5MCHR1 (GPR24)Melanin concentrating hormone receptor 1hormonemelanincontrolweightInhibitorinhibitorinhibit

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