1. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Membrane Transporter/Ion Channel NF-κB Metabolic Enzyme/Protease
  2. Histamine Receptor Calcium Channel Cholinesterase (ChE) Reactive Oxygen Species Amyloid-β
  3. AChE/BChE-IN-21

AChE/BChE-IN-21 is a histamine H3 receptor antagonist, calcium channel blocker, and acetylcholinesterase inhibitor. AChE/BChE-IN-21 exhibits neuroprotective activity against H2O2 and Aβ1-40, and can restore cognitive function in AD mice.

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AChE/BChE-IN-21 Chemical Structure

AChE/BChE-IN-21 Chemical Structure

CAS No. : 2756368-79-1

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Description

AChE/BChE-IN-21 is a histamine H3 receptor antagonist, calcium channel blocker, and acetylcholinesterase inhibitor. AChE/BChE-IN-21 exhibits neuroprotective activity against H2O2 and Aβ1-40, and can restore cognitive function in AD mice[1].

Molecular Weight

630.86

Formula

C38H54N4O4

CAS No.
SMILES

O=C(NC(C1=CC=C(OCCCCCN2CCCCC2)C=C1)C(C(OCC)=O)=C3C)N3CCC4CCN(CC4)CC5=CC=CC=C5

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Room temperature in continental US; may vary elsewhere.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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AChE/BChE-IN-21
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