AChE/BChE-IN-6

Cat. No.: HY-146315: FAQs
Data Sheet Handling Instructions

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AChE/BChE-IN-6 (compound 22) is a potent dual AChE/BChE inhibitor with IC₅₀ values of 0.809 µM, 2.248 µM and > 100 µM for hBChE, hAChE and hMAO-B, respectively. AChE/BChE-IN-6 penetrates the blood-brain barrier (BBB). AChE/BChE-IN-6 can be used for Alzheimer’s disease (AD) research.

For research use only. We do not sell to patients.

AChE/BChE-IN-6 Chemical Structure

CAS No. : 2416910-94-4

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AChE BChE

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MAO-A MAO-B

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

hMAO-B

＞ 100 μM (IC₅₀)

hAChE

2.248 μM (IC₅₀)

hBCHE

0.809 μM (IC₅₀)

In Vitro

AChE/BChE-IN-6 (compound 22) (1-100 µM; 48 hours) can cross the blood-brain barrier and has neuroprotective to human neuronal-like SH-SY5Y and liver HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	SH-SY5Y and HepG2 cells
Concentration:	1-100 µM
Incubation Time:	48 hours
Result:	Had non-cytotoxic at 20 µM on SH-SY5Y cells and at 50 µM on HepG2 cells.

Molecular Weight

366.50

Formula

C₂₃H₃₀N₂O₂

CAS No.

2416910-94-4

SMILES

CC(C1=CC=C(C=C1)NC(OCC2CCN(CC2)CC3=CC=CC=C3)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Košak U, et, al. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents. Eur J Med Chem. 2020 Jul 1;197:112282. [Content Brief]

AChE/BChE-IN-6 Related Classifications

Neurological Disease

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BChE-IN-62416910-94-4Cholinesterase (ChE)Monoamine OxidaseMAOhBChEhAChEhMAO-Bblood-brain barrierAlzheimer’s diseaseSH-SY5YHepG2Inhibitorinhibitorinhibit

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