2. Neuronal Signaling
  3. Monoamine Oxidase Cholinesterase (ChE)
  4. AChE/BChE/MAO-B-IN-3

AChE/BChE/MAO-B-IN-3, an indan-1-one derivative, is a potent MAO-B inhibitor with an IC50 of 0.0359 μM for human MAO-B. AChE/BChE/MAO-B-IN-3 is a potent AChE and BChE enzyme inhibitor, with IC50s of 0.0473 μM and 0.0782 μM for human AChE and BChE enzyme, respectively. AChE/BChE/MAO-B-IN-3 shows significant antioxidant activity and has the potential for Alzheimer's disease (AD) research.

For research use only. We do not sell to patients.

AChE/BChE/MAO-B-IN-3 Chemical Structure

AChE/BChE/MAO-B-IN-3 Chemical Structure

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AChE/BChE/MAO-B-IN-3 Related Antibodies

Top Publications Citing Use of Products

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MAO-A MAO-B

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AChE BChE

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Description

AChE/BChE/MAO-B-IN-3, an indan-1-one derivative, is a potent MAO-B inhibitor with an IC50 of 0.0359 μM for human MAO-B. AChE/BChE/MAO-B-IN-3 is a potent AChE and BChE enzyme inhibitor, with IC50s of 0.0473 μM and 0.0782 μM for human AChE and BChE enzyme, respectively. AChE/BChE/MAO-B-IN-3 shows significant antioxidant activity and has the potential for Alzheimer's disease (AD) research[1].

IC50 & Target[1]

hMAO-B

0.0359 μM (IC50)

hAChE

0.0473 μM (IC50)

hBCHE

0.0782 μM (IC50)

In Vitro

AChE/BChE/MAO-B-IN-3 (compound D38) has the IC50 value of 6.8118 μM on the NIH/3T3 fibroblast cell line[1].
AChE/BChE/MAO-B-IN-3 (1 mM) demonstrates strong human AChE and BChE enzyme inhibition profiles by generating at 93% activity, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AChE/BChE/MAO-B-IN-3 Related Antibodies
Molecular Weight

421.53

Formula

C25H31N3O3
SMILES

O=C(NC1=CC=C(/C=C(CC2=C3C=C(OC)C=C2)/C3=O)C=C1)CN(C)CCCN(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AChE/BChE/MAO-B-IN-3 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BChE/MAO-B-IN-3Monoamine OxidaseCholinesterase (ChE)MAOindan-1-oneMAO-BAChEBChEantioxidant,?Alzheimer's disease ,ADInhibitorinhibitorinhibit

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