AChE/BuChE-IN-3

Cat. No.: HY-147939: FAQs
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AChE/BuChE-IN-3 is a potent and blood-brain barrier (BBB) penetrant AChE and BuChE dual inhibitor with IC₅₀s of 0.65 μM and 5.77 μM for AChE and BuChE. AChE/BuChE-IN-3 also inhibits Aβ_1-42 aggregation. AChE/BuChE-IN-3 has effectively neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE/BuChE-IN-3 can be used for researching Alzheimer's disease.

For research use only. We do not sell to patients.

AChE/BuChE-IN-3 Chemical Structure

CAS No. : 2742707-47-5

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AChE BChE

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

AChE

0.65 μM (IC₅₀)

BChE

5.77 μM (IC₅₀)

In Vitro

AChE/BuChE-IN-3 (compound C4) (12.5-100 μM; 48 hours) exhibits no cytotoxicity on the human neuroblastoma cell line SH-SY5Y, and slightly increases cell viabilities^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	SH-SY5Y
Concentration:	12.5 μM, 25 μM, 50 μM and 100 μM
Incubation Time:	48 hours
Result:	Exhibited no cytotoxicity on the human neuroblastoma cell line SH-SY5Y, and slightly increased cell viabilities.

Molecular Weight

585.57

Formula

C₃₀H₃₀F₃N₃O₆

CAS No.

2742707-47-5

SMILES

FC(C1=CC=C(CN2N=NC(COC3=CC(OC)=C4CCC(C5=CC(OC)=C(OC)C(OC)=C5)OC4=C3)=C2)C=C1)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shi S, et al. Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease. Bioorg Chem. 2020 Jul;100:103917. [Content Brief]

AChE/BuChE-IN-3 Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BuChE-IN-32742707-47-5Cholinesterase (ChE)Amyloid-ββ-amyloid peptideAβAbetaBBB penetrantneuroprotectiveSH-SY5YAlzheimer's diseaseInhibitorinhibitorinhibit

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