AChE-IN-29 

AChE-IN-29, 3-OH pyrrolidine derivative, is an cholinesterase (ChE) inhibitor. AChE-IN-29 has cholinesterase inhibitory activity for hAChE, eeAChE and eqBChE with IC₅₀ values of 0.25 μM, 0.23 μM and 0.72 μM, respectively. AChE-IN-29 can be used for the research of Alzheimer's disease^[1].

IC50: 0.25 μM (hAChE); 0.23 μM (eeAChE); eqBChE (0.72 μM); 24.12 μM (in DPPH assay)^[1]

AChE-IN-29 (VA10) can effectively inhibit the AChE, BChE and Aβ1-42^[1].
AChE-IN-29 has Cholinesterase inhibitory activity for hAChE, eeAChE and eqBChE with IC₅₀ values of 0.25 μM, 0.23 μM and 0.72 μM, respectively^[1].
AChE-IN-29 has significant antioxidant activity with IC₅₀ value of 24.12 μM in DPPH assay^[1].
AChE-IN-29 (5 μM, 10 μM, 20 μM) can inhibit self-induced Aβ1-42 aggregation as well as hAChE-induced Aβ1-42 aggregation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-29 (VA10) (p.o.; 2.5, 5, and 10 mg/kg) ameliorates the memory and cognitive dysfunctions by inhibiting AChE activity^[1].
AChE-IN-29 (p.o.; 10 mg/kg) recovers cell density in hippocampus region^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

375.26

C₁₈H₁₉BrN₂O₂

O=C(C1=CC=C(C=C1)Br)NC2=CC=CC=C2CN3CC[C@@H](C3)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bhanukiran K,et al. Discovery of multi-target directed 3-OH pyrrolidine derivatives through a semisynthetic approach from alkaloid vasicine for the treatment of Alzheimer's disease. Eur J Med Chem. 2023;249:115145.  [Content Brief]