AChE/MAO-IN-2 

Dual AChE-MAO B-IN-5, indanone derivative, is a potent dual AChE/MAO-B inhibitior with IC₅₀ values of 0.0224, 0.0412, and 0.1116 μM for AChE, MAO-B and MAO-A, respectively. Dual AChE-MAO B-IN-5 has antioxidant activity and prevents β-amyloid plaque aggregation. Dual AChE-MAO B-IN-5 can be used for Alzheimer’s disease (AD) research^[1].

Dual AChE-MAO B-IN-5 (conpound D29; 0.1-1 μM) has antioxidant activity with an IC₅₀ value of 0.188 μM^[1].
Dual AChE-MAO B-IN-5 (0.1-1 μM) increases cholinergic activity and prevents the buildup of β-amyloid plaque with inhibitions of 82.748% and 71.891 % for 0.1 μM and 1 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

378.46

C₂₃H₂₆N₂O₃

O=C(NC1=CC=C(/C=C(CC2=C3C=C(OC)C=C2)/C3=O)C=C1)CN(C)CCC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sağlık BN, et, al. Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents. ACS Omega. 2022 Dec 7;7(50):47378-47404.  [Content Brief]