2. GPCR/G Protein
  3. GPR109A
  4. Acifran

Acifran (AY 25712), an antihyperlipidemic agent, is an orally active agonist of GPR109A (HM74A) and GPR109B, the high and low affinity receptors for Niacin.

For research use only. We do not sell to patients.

Acifran Chemical Structure

Acifran Chemical Structure

CAS No. : 72420-38-3

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1 mg USD 50 In-stock
5 mg USD 95 In-stock
10 mg USD 160 In-stock
25 mg USD 320 In-stock
50 mg USD 520 In-stock
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Based on 1 publication(s) in Google Scholar

Acifran Related Antibodies

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Description

Acifran (AY 25712), an antihyperlipidemic agent, is an orally active agonist of GPR109A (HM74A) and GPR109B, the high and low affinity receptors for Niacin[1][2].

Cellular Effect
Cell Line Type Value Description References
CHO-K1 EC50
160 nM
Compound: acifran
Agonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA
Agonist activity at HCA2 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA
[PMID: 25737085]
CHO-K1 EC50
316 nM
Compound: acifran
Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA
Agonist activity at HCA3 receptor (unknown origin) expressed in CHOK1 cells assessed as ERK1/2 phosphorylation by ELISA
[PMID: 25737085]
Molecular Weight

218.21

Formula

C12H10O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C(OC1(C)C2=CC=CC=C2)=CC1=O)O
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (572.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5827 mL 22.9137 mL 45.8274 mL
5 mM 0.9165 mL 4.5827 mL 9.1655 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5827 mL 22.9137 mL 45.8274 mL 114.5685 mL
5 mM 0.9165 mL 4.5827 mL 9.1655 mL 22.9137 mL
10 mM 0.4583 mL 2.2914 mL 4.5827 mL 11.4569 mL
15 mM 0.3055 mL 1.5276 mL 3.0552 mL 7.6379 mL
20 mM 0.2291 mL 1.1457 mL 2.2914 mL 5.7284 mL
25 mM 0.1833 mL 0.9165 mL 1.8331 mL 4.5827 mL
30 mM 0.1528 mL 0.7638 mL 1.5276 mL 3.8190 mL
40 mM 0.1146 mL 0.5728 mL 1.1457 mL 2.8642 mL
50 mM 0.0917 mL 0.4583 mL 0.9165 mL 2.2914 mL
60 mM 0.0764 mL 0.3819 mL 0.7638 mL 1.9095 mL
80 mM 0.0573 mL 0.2864 mL 0.5728 mL 1.4321 mL
100 mM 0.0458 mL 0.2291 mL 0.4583 mL 1.1457 mL
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Acifran Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acifran72420-38-3AY 25712AY25712AY-25712GPR109AHM74APUMA-GHCA2HCAR2 GPR109Bantihyperlipidemic agentNiacin receptorInhibitorinhibitorinhibit

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