2. GPCR/G Protein
  3. Adenosine Receptor
  4. Adenosine 5'-monophosphate disodium

Adenosine 5'-monophosphate disodium 

Cat. No.: HY-W011012 Purity: 99.63%
COA Handling Instructions

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Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes.

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Adenosine 5'-monophosphate disodium Chemical Structure

Adenosine 5'-monophosphate disodium Chemical Structure

CAS No. : 4578-31-8

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Based on 8 publication(s) in Google Scholar

Other Forms of Adenosine 5'-monophosphate disodium:

Adenosine 5'-monophosphate disodium Related Antibodies

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Description

Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes[1][2][3].

IC50 & Target[3]

A2BR

 

In Vivo

Adenosine 5'-monophosphate (10 and 13 mg/L in distilled water, for 25 weeks) disodium improves glucose metabolism in mice with HFD-induced diabetes[1].
Adenosine 5'-monophosphate (40-800 mg/kg, i.p.) lowers body temperature via the adenosine receptor in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 J mice with high-fat diet-induced diabetes[1]
Dosage: 10 and 13 mg/L
Administration: Added in distilled water, for 25 weeks
Result: Enhanced phosphorylation of AMPK and mRNA levels of genes involved in lipid oxidation in the skeletal muscle.
Molecular Weight

391.18

Formula

C10H12N5Na2O7P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(O[Na])(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (255.64 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5564 mL 12.7818 mL 25.5637 mL
5 mM 0.5113 mL 2.5564 mL 5.1127 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.63%

COA (254 KB) HNMR (118 KB) RP-HPLC (221 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.5564 mL 12.7818 mL 25.5637 mL 63.9092 mL
5 mM 0.5113 mL 2.5564 mL 5.1127 mL 12.7818 mL
10 mM 0.2556 mL 1.2782 mL 2.5564 mL 6.3909 mL
15 mM 0.1704 mL 0.8521 mL 1.7042 mL 4.2606 mL
20 mM 0.1278 mL 0.6391 mL 1.2782 mL 3.1955 mL
25 mM 0.1023 mL 0.5113 mL 1.0225 mL 2.5564 mL
30 mM 0.0852 mL 0.4261 mL 0.8521 mL 2.1303 mL
40 mM 0.0639 mL 0.3195 mL 0.6391 mL 1.5977 mL
50 mM 0.0511 mL 0.2556 mL 0.5113 mL 1.2782 mL
60 mM 0.0426 mL 0.2130 mL 0.4261 mL 1.0652 mL
80 mM 0.0320 mL 0.1598 mL 0.3195 mL 0.7989 mL
100 mM 0.0256 mL 0.1278 mL 0.2556 mL 0.6391 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Adenosine 5'-monophosphate disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adenosine 5'-monophosphate disodium4578-31-8Adenosine ReceptorP1 receptorHFDdiabetesAMPKnucleotideATP metabolismInhibitorinhibitorinhibit

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