Adenosine A1 receptor activator T62

Name: Adenosine A1 receptor activator T62
Brand: MedChemExpress
SKU: HY-106199
Rating: 4.5 (1 reviews)

Cat. No.: HY-106199 Purity: 98.93%: FAQs
Data Sheet SDS COA Handling Instructions

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Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain.

For research use only. We do not sell to patients.

Adenosine A1 receptor activator T62 Chemical Structure

CAS No. : 40312-34-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Adenosine A1 receptor activator T62

•SSRN. 2023 May 30.

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Adenosine A₁ receptor (A₁R) Adenosine A_2A receptor (A_2AR) Adenosine A_2B receptor (A_2BR) Adenosine A₃ receptor (A₃R)

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Adenosine A1 receptor^[1]

In Vivo

Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male SpragueDawley rats (250 g) after paw incision surgery^[1]
Dosage:	0.3 μg, 0.5 μg, 1 μg, and 3 μg
Administration:	Intrathecal administration
Result:	Produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED₄₀ (95% confidence interval) was 0.77 (0.63-0.91) μg.

Clinical Trial

Molecular Weight

291.80

Formula

C₁₅H₁₄ClNOS

CAS No.

40312-34-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=C(Cl)C=C1)C2=C(N)SC3=C2CCCC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (342.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4270 mL	17.1350 mL	34.2701 mL
5 mM	0.6854 mL	3.4270 mL	6.8540 mL
10 mM	0.3427 mL	1.7135 mL	3.4270 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.93%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (246 KB) RP-HPLC (207 KB)

Handling Instructions (2659 KB)

References

[1]. Obata H, et al. Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury. Anesthesiology. 2004 May;100(5):1258-62. [Content Brief]

[2]. Li X, et al. Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism. J Pharmacol Exp Ther. 2003 Jun;305(3):950-5. [Content Brief]

[3]. Soudijn W, et al. Allosteric modulation of G protein-coupled receptors: perspectives and recent developments. Drug Discov Today. 2004 Sep 1;9(17):752-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4270 mL	17.1350 mL	34.2700 mL	85.6751 mL
	5 mM	0.6854 mL	3.4270 mL	6.8540 mL	17.1350 mL
	10 mM	0.3427 mL	1.7135 mL	3.4270 mL	8.5675 mL
	15 mM	0.2285 mL	1.1423 mL	2.2847 mL	5.7117 mL
	20 mM	0.1714 mL	0.8568 mL	1.7135 mL	4.2838 mL
	25 mM	0.1371 mL	0.6854 mL	1.3708 mL	3.4270 mL
	30 mM	0.1142 mL	0.5712 mL	1.1423 mL	2.8558 mL
	40 mM	0.0857 mL	0.4284 mL	0.8568 mL	2.1419 mL
	50 mM	0.0685 mL	0.3427 mL	0.6854 mL	1.7135 mL
	60 mM	0.0571 mL	0.2856 mL	0.5712 mL	1.4279 mL
	80 mM	0.0428 mL	0.2142 mL	0.4284 mL	1.0709 mL
	100 mM	0.0343 mL	0.1714 mL	0.3427 mL	0.8568 mL