Adenosine-d (Synonyms: Adenine riboside-d₁; D-Adenosine-d)

Name: Adenosine-d
Brand: MedChemExpress
SKU: HY-B0228S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0228S Purity: 99.72%: FAQs
Data Sheet SDS COA Handling Instructions

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Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].

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Adenosine-d Chemical Structure

CAS No. : 109923-50-4

Size	Price	Stock	Quantity
1 mg	USD 65	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Adenosine-d:

Adenosine In-stock
Adenosine-¹⁵N₅ Get quote
Adenosine-d₁₃ Get quote
Adenosine-¹³C₁₀ Get quote

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

268.25

Formula

C₁₀H₁₂DN₅O₄

CAS No.

109923-50-4

Unlabeled CAS

58-61-7

Appearance

Solid

Color

White to off-white

SMILES

NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=N2)=NC([2H])=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL (124.25 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7279 mL	18.6393 mL	37.2787 mL
5 mM	0.7456 mL	3.7279 mL	7.4557 mL
10 mM	0.3728 mL	1.8639 mL	3.7279 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.72%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (252 KB) HNMR (834 KB) RP-HPLC (764 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007;14(7):1315-1323. [Content Brief]

[3]. Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625. [Content Brief]

[4]. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009;111(4):904-915. [Content Brief]

[5]. Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 2019;41(2):829-838. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7279 mL	18.6393 mL	37.2787 mL	93.1966 mL
	5 mM	0.7456 mL	3.7279 mL	7.4557 mL	18.6393 mL
	10 mM	0.3728 mL	1.8639 mL	3.7279 mL	9.3197 mL
	15 mM	0.2485 mL	1.2426 mL	2.4852 mL	6.2131 mL
	20 mM	0.1864 mL	0.9320 mL	1.8639 mL	4.6598 mL
	25 mM	0.1491 mL	0.7456 mL	1.4911 mL	3.7279 mL
	30 mM	0.1243 mL	0.6213 mL	1.2426 mL	3.1066 mL
	40 mM	0.0932 mL	0.4660 mL	0.9320 mL	2.3299 mL
	50 mM	0.0746 mL	0.3728 mL	0.7456 mL	1.8639 mL
	60 mM	0.0621 mL	0.3107 mL	0.6213 mL	1.5533 mL
	80 mM	0.0466 mL	0.2330 mL	0.4660 mL	1.1650 mL
	100 mM	0.0373 mL	0.1864 mL	0.3728 mL	0.9320 mL

Adenosine-d Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adenosine-d109923-50-4Adenine riboside-d₁D-Adenosine-dNucleoside Antimetabolite/AnalogAutophagyApoptosisEndogenous MetaboliteInhibitorinhibitorinhibit

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Adenosine-d (Synonyms: Adenine riboside-d1; D-Adenosine-d)

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Complete Stock Solution Preparation Table

Adenosine-d Related Classifications

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Adenosine-d (Synonyms: Adenine riboside-d₁; D-Adenosine-d)