2. Stem Cell/Wnt MAPK/ERK Pathway Autophagy
  3. Organoid p38 MAPK Autophagy Mitophagy
  4. Adezmapimod (Standard)

Adezmapimod (Standard)  (Synonyms: SB 203580 (Standard); RWJ 64809 (Standard))

Cat. No.: HY-10256R Purity: ≥98%
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Adezmapimod (Standard) is the analytical standard of Adezmapimod. This product is intended for research and analytical applications. Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator[1].

For research use only. We do not sell to patients.

Adezmapimod (Standard) Chemical Structure

Adezmapimod (Standard) Chemical Structure

CAS No. : 152121-47-6

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Description

Adezmapimod (Standard) is the analytical standard of Adezmapimod. This product is intended for research and analytical applications. Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator[1].

Molecular Weight

377.43

Formula

C21H16FN3OS
CAS No.
SMILES

O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Adezmapimod (Standard) Related Classifications

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Keywords:

Adezmapimod (Standard)152121-47-6SB 203580 (Standard)RWJ 64809 (Standard)Organoidp38 MAPKAutophagyMitophagyMitochondrial AutophagyATP-competitiveSAPK2aSAPK2bLCKGSK3βPKBαInhibitorinhibitorinhibit

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