Dibenzyl trisulfide (Synonyms: DTS)

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Dibenzyl trisulfide (DTS) is an active ingredient that can be isolated from Petiveria alliacea L.. Dibenzyl trisulfide inhibits cell proliferation and migration. Dibenzyl trisulfide decreased the mRNA and protein expression of BAK-1 and LTA. Dibenzyl trisulfide induces lysosomal membrane permeabilization and cathepsin B release.

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Dibenzyl trisulfide Chemical Structure

CAS No. : 6493-73-8

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.4 μM Compound: 4	Antitumor activity against human A2780 cell line by RTCES assay Antitumor activity against human A2780 cell line by RTCES assay	[PMID: 16828553]
HeLa	IC₅₀	2.5 μM Compound: 4	Antitumor activity against human HeLa cell line by RTCES assay Antitumor activity against human HeLa cell line by RTCES assay	[PMID: 16828553]
HepG2	IC₅₀	> 100 μM Compound: 4	Antitumor activity against human HepG2 cell line by RTCES assay Antitumor activity against human HepG2 cell line by RTCES assay	[PMID: 16828553]
HT-1080	IC₅₀	1.9 μM Compound: 4	Antitumor activity against human HT1080 cell line by RTCES assay Antitumor activity against human HT1080 cell line by RTCES assay	[PMID: 16828553]
Jurkat	IC₅₀	0.35 μM Compound: 4	Antitumor activity against human jurkat cell line by MTT assay Antitumor activity against human jurkat cell line by MTT assay	[PMID: 16828553]
MCF7	IC₅₀	6.6 μM Compound: 4	Antitumor activity against human MCF7 cell line by RTCES assay Antitumor activity against human MCF7 cell line by RTCES assay	[PMID: 16828553]
MDA-MB-231	IC₅₀	2.4 μM Compound: 4	Antitumor activity against human M231 cell line by RTCES assay Antitumor activity against human M231 cell line by RTCES assay	[PMID: 16828553]
NCI-H460	IC₅₀	5.1 μM Compound: 4	Antitumor activity against human H460 cell line by RTCES assay Antitumor activity against human H460 cell line by RTCES assay	[PMID: 16828553]
OVCAR-4	IC₅₀	1.4 μM Compound: 4	Antitumor activity against human OVACR4 cell line by RTCES assay Antitumor activity against human OVACR4 cell line by RTCES assay	[PMID: 16828553]

In Vitro

Dibenzyl trisulfide (0.1-50 µM; 2 weeks) inhibits CRL-2335 cell proliferation and migration^[1].
Dibenzyl trisulfide (10, 50 µM; 48 h) decreased the mRNA and protein expression of BAK-1 and LTA in a dose-dependent manner^[1].
Dibenzyl trisulfide (10 µM; 48 h) induces lysosomal membrane permeabilization and cathepsin B release in CRL-2335 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	CRL-2335 cells
Concentration:	0.1, 0.5, 1, 10, 50 µM
Incubation Time:	2 weeks
Result:	Inhibited proliferation and migration of CRL-2335 cell in a dose-dependent manner.

RT-PCR^[1]

Cell Line:	CRL-2335 cells
Concentration:	0, 10, 50 µM
Incubation Time:	48 h
Result:	Decreased the mRNA expression of BAK-1, GADD45a, and LTA in a dose-dependent manner.

Immunofluorescence^[1]

Cell Line:	CRL-2335 cells
Concentration:	0, 10, 50 µM
Incubation Time:	48 h
Result:	Decreased the protein expression of BAK-1 and LTA but not GADD45a.

Molecular Weight

278.46

Formula

C₁₄H₁₄S₃

CAS No.

6493-73-8

SMILES

C1(CSSSCC2=CC=CC=C2)=CC=CC=C1

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Williams LA, et al. Implications of dibenzyl trisulphide for disease treatment based on its mode of action. West Indian Med J. 2009 Nov;58(5):407-9. [Content Brief]

Dibenzyl trisulfide Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dibenzyl trisulfide6493-73-8DTSCathepsinRL-2335 cellsBAK-1LTAcathepsin BInhibitorinhibitorinhibit

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